Co-sensitization to silkworm moth (Bombyx mori ) and 9 inhalant allergens among allergy patients in Guangzhou, Southern China
G. Zeng, B. Sun, P. Zheng (Guangzhou, China)
Source: International Congress 2014 – Clinical allergy
Session: Clinical allergy
Session type: Thematic Poster Session
Number: 4037
Disease area: Airway diseases
Abstract Objectives: This study aimed to investigate the profile of sensitization to silkworm moth (Bombyx mori ) and other 9 common inhalant allergens among patients with allergic diseases in southern China.Methods: A total of 175 patients were tested for serum sIgE against silkworm moth in addition to combinations of other allergens: Dermatophagoides pteronyssinus , Dermatophagoides farinae , Blomia tropicalis , Blattella germanica , Periplaneta americana , cat dander, dog dander, Aspergillus fumigatus and Artemisia vulgaris by using the ImmunoCAP system. Correlation between sensitization to silkworm moth and to the other allergens was analyzed.Results: Of the 175 serum samples tested, 86 (49.14%) were positive for silkworm moth sIgE. With high coincidence rates, these silkworm moth sensitized patients were concomitantly sensitized to Dermatophagoides pteronyssinus (94.34%), Dermatophagoides farinae (86.57%), Blomia tropicalis (93.33%), Blattella germanica (96.08%), and Periplaneta americana (79.41%). Moreover, there was a correlation in sIgE level between silkworm moth and Dermatophagoides pteronyssinus (r = 0.518), Dermatophagoides farinae (r = 0.702), Blomia tropicalis (r = 0.701), Blattella germanica (r = 0.878), and Periplaneta americana (r = 0.531) among patients co-sensitized to silkworm moth and each of these five allergens.Conclusion: In southern Chinese patients with allergic diseases, we showed a high prevalence of silkworm moth sensitization, and a co-sensitization between silkworm moth and other five allergens. Such co-sensitization may also result from cross-reactivity of allergens, rendering future studies needed for clarification.
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G. Zeng, B. Sun, P. Zheng (Guangzhou, China). Co-sensitization to silkworm moth (Bombyx mori ) and 9 inhalant allergens among allergy patients in Guangzhou, Southern China. Eur Respir J 2014; 44: Suppl. 58, 4037
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