Source: Annual Congress 2002 - Asthma and COPD: pharmacology
Disease area: Airway diseases

Abstract

Lung deposition of inhaled corticosteroids is essential for treatment efficacy and safety. Pulmonary deposition of ciclesonide (CIC) was assessed by two dimensional (2D) planar scintigraphy and three dimensional (3D) SPECT scintigraphy. Six healthy subjects inhaled one puff and two healthy subjects inhaled 10 puffs of 50μg CIC using a metered dose inhaler (MDI) containing HFA-134a as propellant. CIC was labeled with 99m-Te prior to administration. 2D-imaging was performed in all 8 subjects, 3D-imaging was performed in the two subjects who received 10 puffs. The 2D deposition characteristics are shown in the table below.

	Mouth/pharynx (%)	Lungs (%)	Mediastinum (%)	Abdomen (%)	Exhaled (%)
Mean	38	52	2	0	9
SD	14	11	1	0	4
Median	34	55	2	0	10
Min	28	25	1	0	2
Max	71	60	3	1	14

In addition, 3D-imaging showed higher peripheral (means: 47% vs. 37%) and lower central (means: 17% vs. 30%) lung deposition when compared to 2D-imaging. Inhalation of 99m-Te labeled CIC was safe and well tolerated. In conclusion, more than 50% of ciclesonide that is inhaled via the MDI is deposited in the lungs in healthy subjects.

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T. D. Bethke, R. J. Boudreau, B. E. Hasselquist, P. Davidson, C. L. Leach, A. Drollmann, B. Hauns, W. Wurst (Konstanz, Germany; Minneapolis, St. Paul, United States Of America). High lung deposition of ciclesonide in 2D- and 3D-imaging. Eur Respir J 2002; 20: Suppl. 38, 746

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