Efficacy of formoterol 12μg dry powder capsules in 6,155 asthmatic patients poorly controlled with salmeterol or on-demand salbutamol (EFORA study)
C. Brambilla, V. Le Gros, I. Bourdeix (Grenoble, France)
Source: Annual Congress 2002 - Asthma and COPD: pharmacology
Session: Asthma and COPD: pharmacology
Session type: Thematic Poster Session
Number: 736
Disease area: Airway diseases
Abstract The efficacy of a 1-month treatment with formoterol (Foradil® Aerolizer™, 12μg b.i.d.) (F) was assessed in asthmatic adults using >=2 puffs/day rescue salbutamol in spite of an inhaled corticosteroid plus either salmeterol 50μg b.i.d.(S) or on-demand salbutamol (PRN). The study was multicentre, open, comparative parallel group and randomized (1/3 no change, 2/3 to receive formoterol). 6,155 patients were assessed (mean age 49.8 years, 51% male): 3,167 patients previously treated with S (1,340 treated with S in Diskus™, 1,827 switched to F), 2,988 previously with PRN (674 treated with PRN, 2,314 switched to F). Results:
PEF (l/min) No symptoms No rescue salbutamol Evening Morning % days % nights % days % nights S [arrowright]S 385.5 383.4 50.0 56.1 53.0 60.9 [arrowright]F 402.9* 398.2* 60.4* 67.2* 65.3* 74.6* PRN [arrowright]PRN 385.0 381.9 42.2 46.6 38.0 51.4 [arrowright]F 409.3* 405.5* 64.9* 70.7* 66.9* 76.3* (mean values, *p<0.001 vs. S or PRN).
Respectively 75% and 82% of the patients previously treated with S or PRN and switched to F, preferred F. In total, 91% of the patients found the Aerolizer™ inhalation device easy or very easy to use, and 85% considered the visual dose confirmation an advantage. All treatments were well tolerated. In conclusion, this study shows that F significantly improves asthma in patients poorly controlled with either PRN or with S.
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
C. Brambilla, V. Le Gros, I. Bourdeix (Grenoble, France). Efficacy of formoterol 12μg dry powder capsules in 6,155 asthmatic patients poorly controlled with salmeterol or on-demand salbutamol (EFORA study). Eur Respir J 2002; 20: Suppl. 38, 736
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
Efficacy of formoterol and beclomethasone dry powder capsules in asthmatic patients sub-optimally controlled with the fixed combination formoterol-budesonide (ALLIANCE study) Source: Eur Respir J 2004; 24: Suppl. 48, 261s Year: 2004
Beclometasone/formoterol administered via extrafine dry powder inhaler in controlled asthmatic patients: Comparison with pMDI and beclometasone monotherapy Source: Annual Congress 2012 - Trials in asthma: asthma exacerbations and severe asthma Year: 2012
A single-dose double-blind study comparing efficacy of two dry powder inhalers containing budesonide and formoterol in asthmatic patients Source: International Congress 2016 – Asthma management Year: 2016
Lung deposition of formoterol in COPD patients: comparison of formoterol HFA pMDI, and formoterol dry powder inhaler Source: Eur Respir J 2007; 30: Suppl. 51, 100s Year: 2007
Lung deposition of the extrafine dry powder fixed combination beclomethasone dipropionate plus formoterol fumarate via the NEXT DPI® in healthy subjects, asthmatic and COPD patients Source: Annual Congress 2011 - Drug delivery and pharmacokinetics I Year: 2011
Aerodynamic characteristics of dry powder inhaler (DPI) single-dose combination of budesonide with formoterol in vitro study validation Source: Annual Congress 2012 - The best of pharmacology treatments of airway diseases: new devices and drugs Year: 2012
Formoterol: a new pMDI CFC free formulation. Efficacy of the 12µg dosage versus a dry powder inhaler in moderate to severe asthmatic patients Source: Eur Respir J 2003; 22: Suppl. 45, 284s Year: 2003
Efficacy and tolerability of formoterol Turbuhaler in 6–11 year old children with asthma, not adequately controlled with inhaled corticosteroids Source: Eur Respir J 2002; 20: Suppl. 38, 430s Year: 2002
Once-daily versus twice-daily administration of mometasone furoate dry powder inhaler (MF-DPI) improves lung function in children with asthma previously maintained on inhaled corticosteroids (ICS) Source: Eur Respir J 2004; 24: Suppl. 48, 164s Year: 2004
Comparison of a formoterol multiple dose dry powder inhaler (MDPI) with a formoterol single dose dry powder inhaler (SDPI) in patients with moderate to severe asthma Source: Eur Respir J 2004; 24: Suppl. 48, 260s Year: 2004
Efficacy and safety of salbutamol delivered via a novel multidose dry powder inhaler in comparison with two conventional dry powder inhalers and a pMDI in asthmatic subjects Source: Eur Respir J 2001; 18: Suppl. 33, 50s Year: 2001
Young children with asthma treated with budesonide inhalation suspension can successfully be transitioned to once-daily budesonide dry powder inhaler Source: Annual Congress 2007 - Anti-inflammatory therapy for childhood asthma Year: 2007
Safety and tolerability of high-dose formoterol via aerolizer and salbutamol via MDI in patients with mild-to-moderate COPD Source: Eur Respir J 2003; 22: Suppl. 45, 285s Year: 2003
Efficacy, safety and cost of budesonide/formoterol in a single inhaler compared with budesonide plus formoterol as separate inhalers Source: Eur Respir J 2002; 20: Suppl. 38, 43s Year: 2002
Cost-effectiveness of budesonide and formoterol in a single inhaler compared to fluticasone in the treatment of asthma Source: Eur Respir J 2001; 18: Suppl. 33, 157s Year: 2001
Lower systemic exposure to corticosteroid for fluticasone propionate/salmeterol (500/50mcg bd) compared to budesonide/formoterol (400/12mcg bd) administered via combination dry powder inhalers in subjects with COPD Source: Eur Respir J 2006; 28: Suppl. 50, 205s Year: 2006
Efficacy of nebulized arformoterol, a long-acting β2 -adrenergic bronchodilator, in patients with COPD Source: Eur Respir J 2006; 28: Suppl. 50, 215s Year: 2006
Formoterol delivered by multi-dose dry powder inhaler (MDDPI) improves nocturnal asthma symptoms Source: Eur Respir J 2005; 26: Suppl. 49, 50s Year: 2005
Early and sustained benefits of budesonide and formoterol in a single inhaler vs fluticasone in moderate asthma Source: Eur Respir J 2001; 18: Suppl. 33, 157s Year: 2001
Addition of formoterol Turbuhaler® to budesonide Turbuhaler® is safe and well tolerated in the long-term treatment of mild asthma: results from the OPTIMA trial Source: Eur Respir J 2001; 18: Suppl. 33, 330s Year: 2001