Features of systemic inflammation in patients with stable COPD N. Sanina, S. Panina (Dnipropetrovs'k, Ukraine)
Source: International Congress 2014 – COPD: points to ponder
Session: COPD: points to ponder Session type: Thematic Poster Session Number: 3631
Disease area: Airway diseasesAbstract One of the leading mechanisms in COPD pathogenesis is a systemic inflammatory process. Study objective was to assess the characteristics of systemic inflammation in stable COPD patients. The study involved 122 patients with COPD II and III stages, 100 men and 22 women, mean age 53,9 ± 0,9 yrs, disease duration 12,4 ± 0,9 yrs, FEV₁ 40,2 ± 2.8%, smoking index 19,6 ± 2,6 yrs.It was revealed increasing of acute phase substances: C-reactive protein, seromucoid, ceruloplasmin, fibrinogen, g – globulins and lipoxin A4 compared to healthy subjects (p < 0.01), which indicates persistence of systemic inflammation in patients even without COPD exacerbation.Lipoxin A4 level correlated statistically significantly and directly with fibrinogen (r = 0,890), g -globulins (r = 0,840), white blood cells count (r = 0,656), mean corpuscular hemoglobin (the sensitive indicator of hemoglobin synthesis) (r = 0,621), erythrocyte sedimentation rate (r = 0,515), C-reactive protein (r = 0,510), lymphocytes and monocytes count (r = 0,451 and r = 0,439), total cholesterol level (r = 0,400) and HDL-cholesterol (r = 0,390). All correlations were significant with p<0,01.Thus, in patients with COPD even without exacerbation observes high level of inflammatory mediators production, activation of lymphocyte cytokine pool, disruption of normal metabolism of arachidonic acid. Therefore, in patients proceeds an active chronic systemic inflammation process, involving cell and plasma active phase indicators with homeostatic imbalance, so, therapy that reduces the intensity of systemic inflammation is a priority even in stable COPD.Rating:
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N. Sanina, S. Panina (Dnipropetrovs'k, Ukraine). Features of systemic inflammation in patients with stable COPD. Eur Respir J 2014; 44: Suppl. 58, 3631
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