Plasma surfactant protein D (SP-D) and smoking status in patients with COPD
K. Gashynova (Dnipropetrovsk, Ukraine)
Source: International Congress 2014 – COPD: points to ponder
Session: COPD: points to ponder
Session type: Thematic Poster Session
Number: 3629
Disease area: Airway diseases
AbstractSPD is a lung derived protein that suggests being specific marker for COPD.The aim of study was to evaluate SP-D level in COPD patients (pts) with different smoking status.Study population and methods. 44 out-patients with stable COPD (Stage II-IV) were surveyed. Plasma SP-D, spirometry and smoking status evaluation were performed for all pts.Results. In accordance with smoking status all pts were divided on three groups: Group I – pts who have never smoked; Group II – current smokers and Group III – ex-smokers.All groups were similar regarding to sex, age, spirometry data and disease duration.SP-D level in pts with different smoking status presents in table 1. Groups | Valid N | Median, ng/dl | Quartiles [25-75 %], ng/dl | I | 5 | 318,61 | 287,60-389,92*# | II | 18 | 889,38 | 407,05-1218,07& | III | 21 | 683,70 | 476,65-1021,73 | Conclusions.Both current and ex-smokers with COPD have significantly higher SP-D level than pts, who have never smoked.The difference in SP-D between current and ex-smokers was not statistically significant. *pI-II = 0,019;# pI-III = 0,018; &pII-III = 0,490 |