Omega-3 polyunsaturated fatty acids in correction of hemostasis system in patients with cor pulmonale
Y. A. Dzyublik, S. I. Leshchenko (Kiev, Ukraine)
Source: Annual Congress 2002 - High altitude and hypoxia
Session: High altitude and hypoxia
Session type: Thematic Poster Session
Number: 699
Disease area: Pulmonary vascular diseases
Abstract A thrombosis in situ of pulmonary microvasculature is an important factor in pathogenesis of cor pulmonale. Attempting to increase the effectiveness of approved therapies, we evaluated the anticoagulative effects of omega-3 polyunsaturated fatty acids (PUFA) in patients with cor pulmonale. We examined 72 patients with right ventricle hypertrophy/dilation, confirmed by echocardiography (COPD - 49, primary pulmonary hypertension - 15, chronic thromboembolic pulmonary hypertension - 8 patients). Only the patients with at least 2 weeks stable pulmonary ventilation and circulation indices were enrolled into the hemostasis study. In addition to the standard therapy we administered patented preparation [dsquote]Tecom[dsquote], containing 45% of EPA/DHA, 4,0 g daily for 4 weeks. The plasma coagulation system was assessed using the following tests: thrombin time, fibrinogen level, plasmolysis time, ethanol test, dissolved fibrin; the platelet function - by means of analysis of ADP-induced platelet aggregation. All tests were performed before and after 4-week treatment period. The application of omega-3 PUFA lowered the incidence of hyperaggregation (50,0±]5,9 before treatment and 33,3±]5,6 cases after, p<0,05) and caused hypocoagulative changes: the levels of dissolved fibrin and fibrinogen decreased (p<0,05). We also noted a positive influence of omega-3 PUFA on blood fibrinolytic activity. Thus, we conclude that proposed therapy can decelerate the intravascular coagulation in patients with impaired pulmonary circulation.
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Y. A. Dzyublik, S. I. Leshchenko (Kiev, Ukraine). Omega-3 polyunsaturated fatty acids in correction of hemostasis system in patients with cor pulmonale. Eur Respir J 2002; 20: Suppl. 38, 699
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