Source: Annual Congress 2002 - High altitude and hypoxia
Disease area: Pulmonary vascular diseases

Abstract

Rationale: COPD is frequently complicated by pulmonary hypertension (PH). Permanent residence at high altitude (above 3.000m) also leads to increase in pulmonary artery pressure and development of PH. Aim: to investigate the particularities of pulmonary circulation in highlanders (HL) with COPD. Methods: invasive measurements of pulmonary hemodynamis were performed in 23 male HL with COPD (2.400-2.700m) on the 7th day after descent to lowland (760m) and in 33 age matched male lowlanders (LL)(760m). All the measurements obtained were recorded at baseline while room air breathing and during hypoxic challenge (breathing gas mixture with FiO2=10% for 30 min). Results are presented in the table. Conclusion. Thus in HL even with moderate COPD severe PH and right ventricular (RV) hypertrophy are occur. Hyperreactivity of pulmonary vascular bed to acute hypoxia is also characteristic in this group of patients.
Legend. Group 1 - HL with moderate COPD; group 2 - LL with moderate COPD; group 3 - LL with severe COPD; RVAWT - RV anterior wall thickness; RVD - RV dimension; p - value of significance.

		Group 1	Group 2	Group 3	P1-2	P2-3	P1-3
MPAP (mm Hg)	Room air	38.4±]1.7	24.7±]1.2	33.0±]1.2	0.000	0.000	0.013
	Hypoxia	48.7±]2.1	33.9±]2.0	40.6±]1.5	0.001	0.013	0.021
SaO2 (%)	Room air	90.2±]1.0	91.3±]0.9	89.7±]1.3	0.492	0.319	0.761
	Hypoxia	65.8±]2.2	67.3±]1.7	64.8±]1.7	0.108	0.022	0.479
RVAWT (cm)		0.59±]0.02	0.46±]0.03	0.52±]0.02	0.029	1.0	0.003
RVD (cm)		2.7±]0.1	2.2±]0.1	2.6±]0.1	0.004	0.017	0.484
FEV1, % pred		47.1±]4.5	43.5±]3.5	25.8±]1.2	0.524	0.000	0.000
FEV1/FVC, (%)		51.7±]3.2	48.4±]2.3	38.4±]2.1	0.401	0.000	0.000

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Citations should be made in the following way:
A. S. Sarybaev, A. S. Sydykov, A. M. Maripov, M. M. Kasymov, M. M. Mirrakhimov (Bishkek, Kyrgyzstan). Pulmonary hypertension due to COPD at high altitude. Eur Respir J 2002; 20: Suppl. 38, 697

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