Source: Annual Congress 2002 - High altitude and hypoxia
Disease area: Pulmonary vascular diseases

Abstract

Development of high altitude pulmonary hypertension (PH) is correlated with desensitization of β-adrenoreceptors (β-AR). We investigated the state of β-AR in lowlanders (LL) and high altitude natives (HL) with PH due to COPD. Pulmonary artery pressure (PAP) was evaluated invasively. β-AR density (Bmax) and dissociation constant (Kd) on the blood lymphocytes were measured at baseline while room air breathing and during hypoxic challenge (FiO2=0.1 for 30 min). Results are presented in the table. Bmax and Kd at baseline in HL with PH due to COPD were significantly higher than in LL. Acute hypoxia decreased Bmax and Kd in LL while increased them in LL. Thus in patients with COPD changes in β-AR density are observed. During acute hypoxia changes of β-AR density depends on the severity of the disease and altitude of residence testifying development of the desensitization of β-AR in severe PH.
Legend. # - p<0,05 compared to group 1; * -p<0,05 - compared to baseline value; Group 1 - HL with moderate COPD; group 2 - LL with moderate COPD; group 3 - LL with severe COPD.

		Group 1 (n=9)	Group 2 (n=9)	Group 3 (n=9)
PAPmean (mm Hg)	Baseline	43,4±]3,2	19,7±]1,1#	33,0±]1,2#
	Hypoxia	53,3±]2,1*	26,4±]2,0*	39,8±]1,5*
Bmax (fmol/106 cells)	Baseline	11,9±]2,41	4,88±]0,39#	3,99±]0,25#
	Hypoxia	7,98±]0,73*	5,56±]0,56	6,73±]0,98
Kd	Baseline	2,3±]0,81	1,62±]0,35	0,61±]0,16#
	Hypoxia	1,01±]0,26*	1,22±]0,24	0,82±]0,43

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A. S. Sarybaev, I. S. Sabirov, A. S. Sydykov, A. A. Aldashev, T. Y. Murzapayazova, M. M. Mirrakhimov (Bishkek, Kyrgyzstan). State of β-adrenoreceptors in pulmonary hypertension due to COPD at high altitude. Eur Respir J 2002; 20: Suppl. 38, 694

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