Source: Annual Congress 2002 - High altitude and hypoxia
Disease area: Pulmonary vascular diseases

Abstract

Abnormal left ventricular (LV) diastolic function (DF) has frequently been reported in patients with chronic pulmonary disease. Several factors including tachicardia, hypoxemia, medications and decreased LV preload may play a role in causing the changes in LV filling profile. In order to investigate LV DF in high altitude pulmonary hypertension (HAPH) we studied 36 highlanders (HL) with HAPH aged 21 to 68 yrs, residing at altitudes of 2900-3600m. Pulmonary hemodynamics and LV DF were evaluated by 2-dimensional and Doppler echocardiography. According to echocardiographic evidence of right ventricular hypertrophy (RVH) [right ventricular dimension (RVD) >2.5cm and anterior wall thickness (RVAWT) >0,5cm] they were divided into 2 groups: 16 HL with high altitude cor pulmonale (HACP) and 20 HL without RVH (HAPH). 18 age matched apparently healthy HL without HAPH serve as control. Results are presented in the table. Thus, our study confirmed that changes occur in LV filling in HL with HAPH and RVH. The interventricular interdependence may play a role in the causing of alterations of LV DF.
Legend. *, **, *** - p<0.05, p<0.01, p<0.001 accordingly for comparison with control group; MPAP - mean pulmonary arterial pressure; E/A - peak E velocity to peak A velocity ratio; FAF - fraction of left atrial filling.

	Control	HAPH	HACP
MPAP, mm Hg	19.0±]0.3	28.2±]0.2***	32.4±]0.8***
RVD, cm	1.84±]0.06	1.95±]0.05	2.73±]0.07***
RVAWT, cm	0.34±]0.01	0.37±]0.01*	0.49±]0.02***
E/A	1.62±]0.07	1.54±]0.06	1.22±]0.12**
FAF, %	23.0±]1.0	25.4±]1.1	31.4±]1.9***

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I. S. Sabirov, A. S. Sydykov, A. M. Maripov, B. K. Kojonazarov, A. S. Sarybaev (Bishkek, Kyrgyzstan). Left ventricular diastolic function in patients with high altitude-induced pulmonary hypertension. Eur Respir J 2002; 20: Suppl. 38, 693

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