Source: Annual Congress 2002 - High altitude and hypoxia
Disease area: Airway diseases, Sleep and breathing disorders

Abstract

Platelets play an important role in the pathogenesis and triggering of acute cardiovascular syndromes. So far, the influence of nocturnal hypoxia on platelet function is not fully understood.
Platelet aggregability to epinephrine in vitro was measured in 20 patients with chronic obstructive pulmonary disease and nocturnal hypoxia (COPD) (60.3+/-11.4 years) and compared with that of 20 controls (51.3+/-12.4 years) at 8 PM, midnight, and 6 AM.
Platelet aggregation in vitro induced by epinephrine remained unchanged in the patients with COPD (67.6+/-24.4 vs. 68.1+/-25.2%; n. s.) whereas it decreased in the controls (75.6+/-18.7 vs. 70.1+/-16.6%; p<0.001).
Our results suggest that nocturnal hypoxia contributes, at least in part, to platelet dysfunction.

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Citations should be made in the following way:
M. Esser, K. Nohtse, M. Haske, M. Tepel, B. M. Sanner (Herne, Germany). Platelet aggregability at night in patients with chronic obstructive pulmonary disease. Eur Respir J 2002; 20: Suppl. 38, 690

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