Source: Annual Congress 2002 - High altitude and hypoxia
Disease area: Pulmonary vascular diseases

Abstract

PURPOSE: The aim of this study was to ascertain the influence of COPD and IPF on ventricular diastolic dysfunction and to compare the two groups.
METHODS: We studied 13 COPD patients (median age, 67yr) and 13 IPF patients with histologically proven disease (median age, 72 yr) with echocardiography. Parameters measured included isovolumic relaxation time (IVRT= time from semilunar valve closure to atrioventricular (AV) valve opening), early and late AV flow velocities (E and A wave, respectively), E/A ratio in right (RV) and left (LV) ventricle. Pulmonary arterial hypertension (PH) was assessed by measuring the systolic pressure of pulmonary artery.
RESULTS: RV IVTR was found abnormal, i.e. >30±]10 ms, in COPD (mean±]SD, 52.7±]17.3) and in IPF patients (38.02±]15.6). This difference is statistically significant (p=0.019). LV IVTR was preserved in both groups (COPD 86.3±]18.4, IPF 80.7±]12.3, p=0.44). The E/A ratio (normal value >1) was found abnormal in both groups, without significant difference between them (p>0.05). Mean+SD PH was moderately increased (46±]14 mmHg) in COPD and mildly (38±]9 mmHg) in IPF (p=0.22).
CONCLUSION: Our results show that both COPD and IPF have a negative influence on ventricular diastolic function and is more prominent in COPD.

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K. M. Antoniou, A. Dermitzakis, G. Meletis, M. Ferdoutsis, G. Patsourakis, N. Tzanakis, N. Bachlitzanakis, D. Bouros (Heraklion, Greece). The influence of pulmonary disease on ventricular diastolic disfunction in COPD and idiopathic pulmonary fibrosis (IPF). Eur Respir J 2002; 20: Suppl. 38, 689

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