Maternal selenium status in pregnancy, glutathione peroxidase 4 genotype and childhood asthma S. Shaheen, C. Rutterford, S. Lewis, S. Ring, J. Holloway, J. Golding, J. Henderson (London, Bristol, Southampton, United Kingdom)
Source: International Congress 2014 – Genes and environment in asthma and COPD
Session: Genes and environment in asthma and COPD Session type: Oral PresentationNumber: 2929
Disease area: Airway diseases, Paediatric lung diseasesAbstract Two previous studies have suggested that higher prenatal selenium exposure may decrease the risk of wheezing in early childhood. We aimed to test whether higher maternal selenium status in pregnancy is associated with a decreased risk of childhood asthma, and whether this association is modified by glutathione peroxidase (GPX) 4 genotype.In the Avon Longitudinal Study of Parents and Children (ALSPAC) we analysed associations between maternal blood concentrations of selenium during pregnancy and childhood asthma (n=2409) and wheezing (n=2438) at 7 years of age. We also explored interactions between maternal selenium and GPX4 genotype (rs713041) on these outcomes.After controlling for confounders, maternal blood selenium concentration was not associated with offspring asthma or wheezing overall. When we stratified by child GPX4 genotype, maternal selenium was not associated with these outcomes in children who carried the C allele of rs713041, however, in children who were homozygous for the minor T allele, maternal selenium was negatively associated with asthma (adjusted odds ratio per doubling concentration 0.15 (95% CI: 0.04 to 0.63), P=0.010) and wheezing (OR 0.16 (0.04 to 0.66), P=0.011), P interaction 0.059 and 0.013, respectively. Conversely, children of mothers in the bottom quintile for blood selenium concentration were more likely to have asthma than children of mothers with higher selenium status, but only if the children were homozygous for the T allele of rs713041 (OR 2.40 (1.07 to 5.41)).Higher maternal selenium status in pregnancy is associated with a decreased risk of asthma in offspring who are homozygous for the T allele of the rs713041 polymorphism of GPX4 .Rating:
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S. Shaheen, C. Rutterford, S. Lewis, S. Ring, J. Holloway, J. Golding, J. Henderson (London, Bristol, Southampton, United Kingdom). Maternal selenium status in pregnancy, glutathione peroxidase 4 genotype and childhood asthma. Eur Respir J 2014; 44: Suppl. 58, 2929
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