e-learning
resources
Munich 2014
Monday, 08.09.2014
Genes and environment in asthma and COPD
Login
Search all ERS
e-learning
resources
Disease Areas
Airways Diseases
Interstitial Lung Diseases
Respiratory Critical Care
Respiratory Infections
Paediatric Respiratory Diseases
Pulmonary Vascular Diseases
Sleep and Breathing Disorders
Thoracic Oncology
Events
International Congress
Courses
Webinars
Conferences
Research Seminars
Journal Clubs
Publications
Breathe
Monograph
ERJ
ERJ Open Research
ERR
European Lung White Book
Handbook Series
Guidelines
All ERS guidelines
e-learning
CME Online
Case reports
Short Videos
SpirXpert
Procedure Videos
CME tests
Reference Database of Respiratory Sounds
Radiology Image Challenge
Brief tobacco interventions
EU Projects
VALUE-Dx
ERN-LUNG
ECRAID
UNITE4TB
Disease Areas
Events
Publications
Guidelines
e-learning
EU Projects
Login
Search
Interaction between interleukin 6 gene polymorphisms and second-hand smoke exposure on adult-onset asthma
T. K. Lajunen, J. J. K. Jaakkola, M. S. Jaakkola (Oulu, Finland)
Source:
International Congress 2014 – Genes and environment in asthma and COPD
Session:
Genes and environment in asthma and COPD
Session type:
Oral Presentation
Number:
2927
Disease area:
Airway diseases
Abstract
Background
We reported strong independent and joint effects of family asthma and second-hand smoke exposure (SHS) on the risk of adult-onset asthma (AJRCCM 2013). For interleukin 6 (IL6), an inflammatory cytokine, up-regulation of gene expression by tobacco smoke, and higher serum levels for smokers and for asthmatics were reported. IL6 single nucleotide polymorphisms (SNPs) were associated with changes in lung function parameters and asthma.
Objective
To assess interactions of IL6 SNPs and SHS on the risk of adult-onset asthma.
Methods
A population-based incident case-control study of clinically defined adult-onset asthma and random controls, among adults 21 to 63 years old in Finland. Six tagging SNPs were genotyped. Among non-smokers, genotyping was available for 217 cases and 316 disease-free controls.
Results
Rs2069827 genotype AA, rs1800797 genotype GA, and rs2069861 genotype AG had synergistic effect with recent SHS exposure. Carriage of any one of them had synergistic effect with SHS, so that the relative excess risk due to interaction (RERI) was 2.22, 95% confidence interval 0.67-5.27, and carriage of any two had even higher synergism (RERI 7.83, -0.02-79.68). In a haplotype analysis of the same SNPs, carriage of haplotype H4 (CAA) or H6 (AAG) (except for a protective haplotype pair H3/H6) was found to show synergism with SHS, RERI 3.05 (-0.66-15.46) and 2.19 (-0.20-8.70), respectively. For of H4 and H6 carriers combined, a synergistic effect was again seen (RERI 3.43, 0.76-10.03).
Conclusions
IL6 SNPs and SHS have synergistic effect on the risk of adult-onset asthma, carriage of several risk genotypes or a risk haplotype is associated with higher synergistic effect.
Rating:
You must
login
to grade this presentation.
Share or cite this content
Citations should be made in the following way:
T. K. Lajunen, J. J. K. Jaakkola, M. S. Jaakkola (Oulu, Finland). Interaction between interleukin 6 gene polymorphisms and second-hand smoke exposure on adult-onset asthma. Eur Respir J 2014; 44: Suppl. 58, 2927
You must
login
to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
No comment yet.
You must
Login
to comment this presentation.
Related content which might interest you:
Panel discussion: Lung function in epidemiological studies from infancy to childhood with focus on urban environment
Late Breaking Abstract - Implications of treatable traits and treatment choices on exacerbation risk in moderate-severe asthma
Observational cohort study of pulmonary exacerbations in alpha-1 antitrypsin deficiency
Related content which might interest you:
Interleukin 33 (IL33) polymorphisms associate with incident adult-onset asthma
Source: International Congress 2015 – Genetics, genomics and exposures in asthma and COPD
Year: 2015
Re-sequencing of
IL33
and
IL1RL1
in severe asthma patients identifies novel variation
Source: International Congress 2014 – Genes and environment in asthma and COPD
Year: 2014
Differences in association between endotoxin and asthma and wheeze with environmental exposures
Source: International Congress 2015 – Indoor air and ambient pollution
Year: 2015
Relation of IL-33 and PSMA6 gene polymorphisms in asthma patients
Source: International Congress 2016 – Clinical studies in asthma and immunology
Year: 2016
Influence of gene-by-early environmental tobacco smoke exposure interactions on time-to-asthma onset
Source: International Congress 2016 – Predictors of asthma among children and adults
Year: 2016
Genetic interaction between
ATP2A2
and
ORMDL3
, a calcium handling origin of asthma
Source: International Congress 2014 – Genes and environment in asthma and COPD
Year: 2014
Environmental tobacco smoke (ETS) induced immunologic changes in children with asthma
Source: International Congress 2014 – Paediatric asthma: epidemiology and risk factors
Year: 2014
Effect of ADRB2 gene polymorphism on treatment outcomes in asthmatics: Cold airway hyperresponsiveness and asthma control
Source: International Congress 2014 – Genetics and environmental factors underlying asthma and COPD
Year: 2014
Gene-by-occupational exposure interaction and gene expression analysis on the level of FEV
1
Source: International Congress 2014 – Genes and environment in asthma and COPD
Year: 2014
Association between genetic polymorphisms of ADAM33 with asthma and its phenotypes
Source: International Congress 2015 – Genetics and environmental factors in phenotypes of asthma and COPD
Year: 2015
Long term effects of environmental tobacco smoke in the European Community Respiratory Health Survey II
Source: Annual Congress 2006 - Highlights of asthma epidemiology
Year: 2006
Implication of interleukin-10 in the development of COPD induced by cigarette smoke exposure in mice
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013
Age-dependent influence of ADRB2 gene polymorphisms on asthma severity in Serbian population
Source: International Congress 2014 – Basic and translational research in asthma and COPD
Year: 2014
Effects of prenatal tobacco smoke exposure on pulmonary signaling networks in a murine model
Source: International Congress 2014 – Mechanistic murine studies of asthma and lung inflammation
Year: 2014
Association of glucocorticoid receptor gene polymorphism with asthma in the Volga-Ural region of Russia
Source: International Congress 2014 – Genetics and environmental factors underlying asthma and COPD
Year: 2014
Novel genes associated with the level of FEV1 in never-smokers in the context of occupational exposure
Source: International Congress 2015 – Genetics, genomics and exposures in asthma and COPD
Year: 2015
Interactions of genetic variants and DNA-M of TSLP modify the eczema risk
Source: International Congress 2016 – Role of genetics and exposures in COPD and asthma
Year: 2016
Genetic differences in COPD secondary to wood smoke and tobacco smoking
Source: Annual Congress 2013 –Genetics and genomics of lung disease
Year: 2013
Polymorphisms in all three
ORMDL
genes are associated with asthma and their mRNA expression is increased in asthmatics
Source: International Congress 2014 – Paediatric asthma: pathogenesis and immunology
Year: 2014
Exposure to siblings in early life modifies the association between CD14 polymorphisms and allergic sensitization in adult life
Source: International Congress 2015 – Understanding paediatric asthma and allergy: genetics and environment
Year: 2015
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking "Accept", you consent to the use of the cookies.
Accept