Source: Annual Congress 2002 - Cell biology and genetics of COPD and emphysema
Disease area: Airway diseases

Abstract

Objective To evaluate the effect and molecular mechanism of retinoic acid(RA) on inhibiting the pathogenesis of experimental pulmonary emphysema in rat. Methods The rat emphysema model was established by exposed to cigarette smoke. Drug intervention group received daily RA before passive smoking. At the second day after the rat model was established, the pulmonary function indices and the histopathological changes were evaluated, the enzymatic activity of gelatinases were measured by ELISA, the expression of gelatinases and PCNA were also examined by means of immunohistochemical method. Results There was a significantly decrease in the number of alveolar and the content of elastin in lung tissue of the model group than the normal group(P<0.01), the FEV0.3, FEV0.3 /FVC was lower, wherease FRC and Cld was more than that of normal group(P<0.01), the enzymatic activity and the expression of gelatinases were also markedly elevated(;P<0.01);.In comparision with the model group ,the extent of emphysematous damage of the drug intervention group were greatly ameliorated(P<0.05), part of the pulmonary function was improved(P<0.05), and the enzymatic activity and the expression of gelatinases were also decreased, the expression of PCNA was increased(P<0.05~0.01).
Conclusion RA can effectively block the development of pulmonary emphysema in rat.

Rating:

Share or cite this content

Citations should be made in the following way:
L. An, Y. H. Zhang, S. B. Pang (Beijing, China). Prophylactic effect of retinoic acid on chronic obstructive pulmonary emphysema in rat. Eur Respir J 2002; 20: Suppl. 38, 646

Member's Comments

No comment yet.

Related content which might interest you: Role of inhaled antioxidants in chronic obstructive pulmonary disease Source: Eur Respir J 2005; 26: Suppl. 49, 717s Year: 2005 Effect of systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease Source: Eur Respir J 2006; 28: Suppl. 50, 624s Year: 2006 Effect of nintedanib on hyaluronic acid metabolism in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis Source: International Congress 2015 – IPF: from bench to bedside Year: 2015 Fenspiride efficacy in the treatment of chronic obstructive pulmonary disease Source: International Congress 2017 – Novel mechanisms and treatments for COPD Year: 2017 Application of erdosteine in the treatment of occupational chronic obstructive pulmonary disease Source: International Congress 2019 – COPD clinical trials: inhaled and oral therapies Year: 2019 Systemic effects of chronic obstructive pulmonary disease Source: Eur Respir J 2003; 21: 347-360 Year: 2003 The effect of short-acting beta-two-agonist on pulmonary rehabilitation in chronic obstructive pulmonary disease Source: Annual Congress 2009 - Pulmonary rehabilitation: extending the scope and benefit of rehabilitation for patients with chronic respiratory disease Year: 2009 Uric acid, oxidative stress and inhaled steroids in stable chronic obstructive pulmonary disease Source: Eur Respir J 2006; 28: Suppl. 50, 428s Year: 2006 Acute effects of sildenafil in chronic obstructive pulmonary disease (COPD) Source: Annual Congress 2008 - Pulmonary hypertension I Year: 2008 Serum lysophosphatidic acid levels and exacerbation frequency in chronic obstructive pulmonary disease (COPD) Source: Virtual Congress 2020 – Ageing, metabolic syndrome and the lung Year: 2020 Effects of inhaled Iloprost on hemodynamics in chronic obstructive pulmonary disease Source: Eur Respir J 2002; 20: Suppl. 38, 27s Year: 2002 Inferon efficacy in the treatment of chronic obstructive pulmonary disease Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD Year: 2008 Suppressed pulmonary expression of leptin in lipopolysaccharide-induced acute and chronic lung inflammation Source: Annual Congress 2006 - Novel pathogenic aspects of acute lung injury and acute respiratory distress syndrome (ARDS) Year: 2006 Effect of 3-week pulmonary rehabilitation on airway inflammation in patients with chronic obstructive lung diseases Source: Annual Congress 2007 - Current issues in airway physiology, pharmacology and monitoring Year: 2007 The effect of nutrition on the pulmonary functions in chronic obstructive pulmonary disease Source: Eur Respir J 2003; 22: Suppl. 45, 538s Year: 2003 Inferon administration to patients with chronic obstructive pulmonary disease Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation Year: 2009 Differential metabolism of hyaluronic acid in patients with idiopathic pulmonary fibrosis Source: International Congress 2015 – IPF: from bench to bedside Year: 2015 Acute exacerbations of idiopathic pulmonary fibrosis and the role of corticosteroids Source: Breathe, 16 (3) 200086; 10.1183/20734735.0086-2020 Year: 2020 Effects of severity of chronic obstructive pulmonary disease on thyroid function Source: Eur Respir J 2005; 26: Suppl. 49, 509s Year: 2005 Efficacy of lasolvan in the treatment of patients with chronic obstructive pulmonary disease Source: Annual Congress 2009 - Drug effects in COPD Year: 2009