Source: Annual Congress 2002 - Cell biology and genetics of COPD and emphysema
Disease area: Airway diseases

Abstract

Coexistence of thromboembolic disease with stage III COPD has been noted postmortem (>50%).In this study we tried to find any correlation between cellular indices of hypercoagulability and the severity of the disease.We studied 61 patients during COPD exacerbation and 25 healthy individuals. We examined the total platelet number (PLT),their size, their activity, the factors that participate to their activation [β-Thromboglobulin (β-TG),Platelet Factor 4(PF4) and β-TG/PF4], the correlation between PLT number and their mean corpuscular volume (MVP) with PF4,β-TG,β-TG/PF4, PaO₂,PaCO₂ and pH.In the COPD group the mean value of the PF4 and β-TG was two and almost six times over the equivalent value of the control group respectively (p<0.001).The mean value of the β-TG/PF4 fraction was significantly higher (p<0.001).This presumably implies chronic in vivo platelet activation in the COPD patients.The PLT number in every COPD patient had a statistically significant positive correlation with the PaO₂ (r=0.298,p<0.002) and pH (r=0.375,p<0.003) value and the MVP with the PF4 and the β-TG(p<0.001).We conclude that in patient with exacerbation of severe COPD,platelets are found to be less in number,larger and hyperactivated compared to healthy individuals.

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Citations should be made in the following way:
K. Konstantinou, A. Paridou, A. Traulou, M. Toubis, G. Dimopoulos, A. Rasidakis (Athens, Greece). Platelets activation during chronic obstructive pulmonary disease (COPD) exacerbation. Eur Respir J 2002; 20: Suppl. 38, 643

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