Possible use of exhaled breath condensate (EBC) for continuous monitoring of lung inflammation in artificial ventilation
G. Becher, G. Schmid, C. Lehmann, S. Dietze, M. Rothe (Berlin, Gross Doelln, Germany)
Source: Annual Congress 2002 - Monitoring respiratory parameters in critically ill patients
Disease area: Airway diseases
Abstract Continuous monitoring of lung function in case of artificial ventilation is still an unsolved problem. Symptoms of light decreases in lung function and early stages of airway inflammation are covered by artificial ventilation. Monitoring of markers of inflammation should improve the early detection of pathological changes in airway epithelium. A couple of non volatile substances are known to be exhaled. In breath condensate the concentration is up to 10000 * higher than in exhaled air, but still 1/1000 of known serum levels. The aim of the study was to prove breath condensate for markers of inflammation and changing of epithelial properties. Intravenous administration of a test-substance, thymol, leads to a wash out curve in serum and in EBC. The concentration in EBC was approximately 1/1000 of the serum level. Exhaled hydrogen peroxide was measured by an Biosensor with a detection limit of 12,5 nmol. The onset of lung damage by free oxygen radicals and the beginning of airway inflammation is sensitive to measure by exhaled hydrogen peroxide. It was shown that continuous monitoring of hydrogen peroxide in exhaled air is a sensitive marker of airway damage. The correlation between serum level and level of marker substances in EBC should be one possibility to detect light changes in epithelial diffusion capacity, onset of lung edema and changes in alveolar lining fluid.
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G. Becher, G. Schmid, C. Lehmann, S. Dietze, M. Rothe (Berlin, Gross Doelln, Germany). Possible use of exhaled breath condensate (EBC) for continuous monitoring of lung inflammation in artificial ventilation. Eur Respir J 2002; 20: Suppl. 38, 621
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