Source: Annual Congress 2002 - Monitoring respiratory parameters in critically ill patients
Disease area: Respiratory critical care

Abstract

INTRODUCTION: Peak inspiratory pressure (PIP) is expected to increase in parallel to the VT magnitude. In the present study we examine the type of this relation in mechanically ventilated ARDS patients, as well as in a control group of patients without respiratory disorder (WRD). METHODS: Five ARDS and six other mechanically ventilated patients without respiratory disorder (WRD) are included in the study. Measurements were done at 14 c/min and six different levels of VT (300 - 800 ml) without PEEPe. PIP (as actual values and as % of the value at VT=300 ml) was correlated to VT with the aid of linear regression. RESULTS & CONCLUSIONS: Values of PIP were significantly higher in the ARDS than in the WRD group. A significant correlation is observed between the actual PIP and VT for the WRD (r=0.74, p<0.001) and for the ARDS groups (r=0.71, p<0.001). The corresponding correlations became stronger when the % PIP values were used for the WRD (r=0.96, p<0.001) and the ARDS group (r=0.85, p<0.001). A lower rate of PIP increase with VT is observed in the WRD group (slope: 0.02) than in the ARDS group (slope: 0.03). On the contrary the %PIP rate of increase with VT is higher in the WRD group (slope: 0.15) than in the ARDS group (slope 0.12). The influence of VT on PIP is not significantly different in ARDS and in WRD groups. The strong correlation of PIP to VT is clinically useful for the regulations of ventilatory settings in ARDS.

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A. Amygdalou, C. Katsanos, C. Leontaridi, M. Moukas, S. Katsenos, C. Mandragos, S. H. Constantopoulos, P. K. Behrakis, M. P. Vassiliou (Ioannina, Athens, Greece). Relationship between peak inspiratory pressure and tidal volume during mechanical ventilation in ARDS. Eur Respir J 2002; 20: Suppl. 38, 619

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