Source: International Congress 2014 – Different interesting issues in respiratory infections: 1
Disease area: Respiratory infections

Abstract

Aims: Respiratory viral infections (RVI) are common and may be serious. Thus, we investigate the prevalence and characteristics of RVI in community acquired pneumonia (CAP) and exacerbation of COPD. Methods: A prospective observational cohort study was conducted in Kyorin University Hospital under the institutional approval, Tokyo, Japan from August 2012 to August 2013.Patients who were admitted on CAP and exacerbation of COPD were included and their respiratory samples and clinical data were obtained after informed consent, and analyzed using a PCR method to identify common respiratory viruses . Results: Fifty-five subjects, which consisted of CAP (n=45, male 29: female 16, mean age 72) and COPD (n=10, male7: female 3, mean age 73) were enrolled. Proportions of viral detection in CAP and exacerbation of COPD were 13% (6/45) and 50% (5/10), respectively. Three cases in CAP were co-infected with bacteria, while co-infection with bacteria was not detected in COPD. Identified viruses in CAP were human rhinovirus: HRV (n=2), human metapneumovirus: HMPV (n=3) and parainfluenza virus (n=1). Detected viruses in COPD exacerbation were respiratory syncytial virus: RSV (n=2) influenza virus (n=1) HMPV (n=1) and HRV (n=1). Two patients died within 30 days among patients with CAP, although any viral were not detected in these patients. On the contrary, three patients died in COPD exacerbation, two patients died of RVI. Conclusion: RVI were noted in about 13 % and 50 % of hospitalized CAP and exacerbation of COPD patients. RVI in hospitalized patients with exacerbation of COPD were a major cause and lead to fatal course.

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D. Kurai, T. Saraya, H. Ishii, H. Tukagoshi, H. Kimura, H. Takizawa (Tokyo, Gunma, Japan). Respiratory viral infections in community-acquired pneumonia and exacerbation of COPD: One year survey at a Japanese university hospital. Eur Respir J 2014; 44: Suppl. 58, 2563

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