Source: International Congress 2014 – Different interesting issues in respiratory infections: 1
Disease area: Respiratory critical care, Respiratory infections

Abstract

Aim: to determine the significance of immunological (CD4, CD8) and inflammatory (procalcitonin (PCT)) markers as predictors of survival in patients with severe CAP.Methods: 51 patients with verified severe CAP without HIV (age – 57,50±4,31 years, men – 37 (72,5%), women – 14 (27,5%)). General analysis, determination of serum PCT, blood CD4, CD8 prior antibacterial treatment (ABT) (visit 1), on 8–10 day of ABT (visit 2), cluster analysis.Results: in 6 (11,7%) patients with severe CAP, despite adequate ABT, lethal end of disease was determined. All patients were divided into 3 classes: 1) whose PCT at visit 2 decreased by more than 95,6% and CD4 increased significantly (by more than 335,7%) we can predict recovery with a maximal probability; 2) patients whose PCT at visit 2 decreased by more than 95,3% and CD4 increased by more than 4,7%, have a chance to recover, although the risk of death and pulmonary complications is high; 3) patients whose PCT decreased very slightly (by 1%) or significantly increased (by more than 11,460%) and CD4 decreased by more than 50% have a maximum risk of death.Conclusions: with a substantial decrease of PCT and increase of CD4 during the adequate ABT a favorable outcome of severe CAP can expect, whereas at the increasing of PCT and decreasing of CD4 the survival is unfavorable.

Rating:

Share or cite this content

Citations should be made in the following way:
K. Bielosludtseva, T. Pertseva (Dnipropetrovsk, Ukraine). Survival predictors of severe community-acquired pneumonia (CAP): Multivariate analysis of immunological and inflammatory parameters. Eur Respir J 2014; 44: Suppl. 58, 2559

Member's Comments

No comment yet.

Related content which might interest you: Clinical and laboratory predictors of survival in patients with severe community-acquired pneumonia (CAP) Source: International Congress 2014 – Healthcare, prevention and adjunctive treatments in respiratory infections Year: 2014 Effectiveness of immune stimulatory therapy in patient with severe community-acquired pneumonia (CAP) Source: International Congress 2014 – Different interesting issues in respiratory infections: 1 Year: 2014 Analysis of the lethal outcomes in patients with severe pneumonia Source: International Congress 2014 – Clinical problems in acute and chronic lung diseases Year: 2014 Features of systemic inflammation in patients with severe community-acquired (CAP) pneumonia of different etiology in HIV-infected patients Source: International Congress 2015 – Immunodepression and severe pneumonia Year: 2015 Role of procalcitonin in predicting severity and in-hospital mortality in patients with community-acquired pneumonia Source: International Congress 2016 – Community-acquired pneumonia: risk classes and management issues Year: 2016 Cardiac autonomic alterations impact early and late outcomes in patients with community-acquired pneumonia Source: Annual Congress 2013 –Manifestations, scores and prognosis of community-acquired pneumonia Year: 2013 The neutrophil/lymphocyte ratio in predicting outcome for hospitalized patients with community-acquired pneumonia Source: International Congress 2014 – Cells, biofilms and biomarkers in respiratory infections Year: 2014 YKL-40 and CCL18 predict mortality in patients hospitalised with community-acquired pneumonia; an observational analysis Source: International Congress 2016 – Community-acquired pneumonia: from prevention to treatment Year: 2016 Community-acquired pneumonia with severe sepsis: Etiology and prognosis Source: Annual Congress 2013 –Pneumonia and sepsis Year: 2013 Effect of acenitobacter baumanii positive pneumonia on morbidity and mortality of patients Source: Annual Congress 2013 –Interesting cases of respiratory infections Year: 2013 Shortening duration of antibiotic therapy according to clinical stability in patients with community-acquired pneumonia (CAP) Source: International Congress 2014 – Respiratory infections: inflammation and treatment Year: 2014 Predictors of treatment failure in patients with bacteremic pneumococcal community-acquired pneumonia Source: Annual Congress 2013 –Pneumonia and sepsis Year: 2013 The outcome of community-acquired pneumonia in patients with COPD, asthma and ILD - a case-control study Source: International Congress 2014 – Epidemiology, scores and outcomes of respiratory infections Year: 2014 Comparison of severity scores to predict outcomes in elderly patients with community acquired pneumonia Source: International Congress 2015 – CAP: prognostic factors in frail patients Year: 2015 Factors affecting short and long-term mortality after community-acquired pneumonia Source: International Congress 2015 – CAP: prognostic factors in frail patients Year: 2015 Assessment of severity of intensive care unit-acquired pneumonia and association with aetiology Source: Annual Congress 2013 –Infection, sepsis and outcomes in ICU Year: 2013 Risk factors and outcomes of severe influenza pneumonia with bacterial co-infection in critically ill patients Source: International Congress 2017 – Sepsis, infections, ARDS and beyond Year: 2017 Comparison of inflammatory response biomarkers to predict complications in hospitalized patients with community-acquired pneumonia Source: Annual Congress 2011 - Biomarkers and outcomes of community-acquired pneumonia Year: 2011 Prognostic factors of 30 day mortality in HIV infected patients with community-acquired pneumonia Source: International Congress 2014 – Interventions and other therapeutic approaches in respiratory infections Year: 2014 Biomarkers as complication predictors in community-acquired pneumonia Source: Annual Congress 2011 - Biomarkers and outcomes of community-acquired pneumonia Year: 2011