Source: Annual Congress 2002 - Treatment and outcome of acute respiratory failure in chronic disease
Disease area: Airway diseases

Abstract

It is known that oxidative stress is induced through the process hypoxia-reoxygenation. The aim of this study was to investigate if long flow oxygen therapy (15 hrs/day, 2 L O₂/min) contributes in the imbalance oxidant/antioxidant in COPD. Sixteen stable, non-smoking (since 6 months), COPD patients were recruited (15 men and 1 woman). Eight patients (mean (SD) age 65.1 (8.6) years) had oxygen therapy 15hrs/day since one year (B1), whereas eight others (B2) (mean (SD) 63.4 (9.6) years) without oxygen therapy were considered as control group. One month before study, all patients had stopped antioxidant and corticoïd treatments. Oxidant system was measured by pentane in expired gas and by malondialdehyde (MDA) in blood. Antioxidant system was evaluated by superoxide dismutase (SOD), glutathion peroxidase (GPX) and total antioxidant status(TAS). Samples were collected in the morning, one hour after stopping oxygen therapy. There was no significant difference between B1 and B2 for all parameters: pentane (pmol/kg/min) 1.2(0,7) vs 2,9(4) ; MDA (μmol/l) 1.77(0.29) vs 1.61(0.36) ; TAS (mmol/l)1.1(0.1) vs 1.1(0.1) ; SOD (U/gHb) 1254(206) vs 1140(117) ; GPX (U/gHb) 30(10) vs 29(5). These results suggest that the threshold of oxygen therapy (FiO₂~0.3) does not cause modification of the oxidant-antioxidant balance in our COPD population.

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M. N. Loiseaux-Meunier, M. Bedu, L. NGuyen, A. Belhadj, J. Coudert, D. Caillaud (Clermont-Ferrand, France). Oxidative stress in patients with COPD: does oxygenotherapy (15 hrs/day) contribute to modify oxidant-antioxidant balance?. Eur Respir J 2002; 20: Suppl. 38, 600

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