LATE-BREAKING ABSTRACT: Cytoreduction surgery and hypertermic intraoperative intrapleural chemotherapy for malignant pleural diseases: initial experience
M. migliore, D. calvo, A. criscione, C. viola, M. gangemi, F. borrata, H. Soto Parra, N. Ciancio, G. Privitera, C. Spatola, G. Di Maria (Catania, Italy)
Source: International Congress 2014 – Risk assessment and tracheal reconstructions
Session: Risk assessment and tracheal reconstructions
Session type: Oral Presentation
Number: 1917
  
AbstractIntroduction: Hyperthermic-intraoperative-intrapleural-chemotherapy has been reported as a promising approach for malignant-pleural-mesothelioma. To clarify the role of cytoreductive surgery for malignant pleural diseases followed by HIOC a prospective study was initiated.Method: criteria of inclusion were good performance status, disease confined within the chest in stage-IV-lung-cancer. CT/PET-scan was always performed. A VATS-approach was used. All macroscopic disease was removed except over the SVC. Following operation cisplatin was administred for 60 min at the dose of 100mg/m2 at the temperature of 42.5 C.Results: 8 patients, mean age 63.7 yo (54-78). Three patients with MPM were right sided TNM staging in MPM was II-III. Postoperative blood transfusion was necessary in 2 pts. One patient died at 6-months.Demographic data, type of surgery, survival | N° | SEX, AGE | PLEURAL EFFUSION | SURGERY | HOSPITAL STAY (days) | COMPLI-CATIONS | HISTOLOGY | SURVIVAL (months) | | 1 | M, 72 | NO | P/D | 6 | NO | EPITHELIOID MPM | 6 (died) | | 2 | M, 59 | YES | P/D | 9 | NO | EPITHELIOID MPM | 19 (alive) | | 3 | M, 61 | YES | P/D, WR (1) | 9 | NO | EPITHELIOID MPM | 14 (alive) | | 4 | F, 54 | NO | P/D, WR (1) | 8 | NO | LUNG ADENOCA | 13 (alive) | | 5 | M, 77 | YES | P/D | 10 | NO | EPITHELIOID MPM | 11 (alive) | | 6 | M, 73 | NO | P/D | 7 | NO | EPITHELIOID MPM | 8 (alive) | | 7 | M, 55 | NO | P/D, RIB RESECTION, WR (1) | 9 | NO | LUNG ADENOCA | 3 (alive) | | 8 | F, 59 | YES | P/D, WR (1) | 6 | ANAEMIA | BIPHASIC MPM | 2 (alive) |
Mean-Hospital-stay was 8 days. Mean survival was 12.9 m.Conclusion: our initial experience shows that cytoreduction and HIOC seems to be a feasible surgical method in the multimodality treatment of for malignant pleural disease.
P/D: pleurectomy-decortication, WR: wedge resection |