Source: Annual Congress 2002 - Lung cancer: epidemiology and clinical characteristics
Disease area: Thoracic oncology

Abstract

During 2000, 1044 pts with malignant lung tumors were analyzed, out of whom 47(5%) had bone metastases, 36(77%) males aged 58 years on average and 11(23%) females mean age 61 years. The diagnosis of malignant tumor was made in 24(51%) by bronchologic tests, in 4(9%) by FNAB of lung changes, in 4(9%) cases by bone biopsy, in 3(6%) pts by exploratoy thoracotomy, in 2(4%) by lymph node biopsy, while diagnosis could not be made in 10(21%) cases. Histopathologic findings were as follows: Adenocarcinoma was found in 18(38%)pts, Squamous Cell Carcinoma in 14(30%), Small Cell Lung Carcinoma in 4(9%), Bronchioalveolar Carcinoma in 1(2%) patient, and no diagnosis was made in 10(21%) cases. After the surgery, bone metastases were detected in 6 pts, and accordingly, symptomatic treatment was applied in 3 pts, one received chemotherapy, one had radiation therapy, and there was one lethal outcome. The remaining 10(21%) cases were administered chemotherapy, 3(6%) pts were given radiation therapy, 1(2%) received combined chemo and radiation therapy, 22(47%) of them had symptomatic treatment, while 5(11%) cases died during the diagnosis. The diagnosis was based on bone radiography and scintigraphy. Higher level of alkaline phosphatase in serum was found in all pts(100%). The bones most frequently involved were: ribs, vertebrae, humerus and femur. It may be concluded that Adenocarcinoma was the most frequent type of tumor to metastasize in bones, the most common aspect of therapy was palliative treatment, lethal outcome during diagnosis occurred in 5(11%) cases, while pamidronate was successfully applied in one patient who had undergone surgery and received chemotherapy.

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Citations should be made in the following way:
T. Adzic, G. Radosavljevic-Asic, N. Samardzic, S. Filipovic, D. Jovanovic (Belgrade, Yugoslavia). Bone metastases of bronchial cancer. Eur Respir J 2002; 20: Suppl. 38, 576

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