Bronchial epithelium changes occurring between the 2nd and the 5th post-biopsy day R. Ganjanin, I. Klem, Z. Eri, J. Stanic (Sremska Kamenica, Yugoslavia)
Source: Annual Congress 2002 - Lung cancer: epidemiology and clinical characteristics
Session: Lung cancer: epidemiology and clinical characteristics Session type: Thematic Poster Session Number: 575
Disease area: Thoracic oncologyAbstract The superficial epithelium of the bronchus develops regenerative changes at a former biopsy site. These regenerative changes can easily be misinterpreted for epidermoid lung cancer. The closest resemblance is registered between the 2nd and the 5th post-biopsy day. Sixty-six biopsy samples analysed were subdivided into two groups of 33 subjects each, either undergoing a rebiopsy within the 2nd-5th day interval following a former biopsy, or having the diagnosis of epidermoid lung cancer already established. Both groups were analysed for the same morphological parameters and then z-tested, with a 5% error risk (a = 0.05). The morphological changes characterizing the regenerating epithelium are: fibrin (z=4.41; P=0.000), granulocytes (z=4.79; P=0.000), granulocytes within the epithelium (z06.92; P=0.000), infiltrations into the granulation tissue. The tumorous tissue is however characterized by the presence of mononuclears (z=3.63; P=0.0003), dyskeratosis (z=4.29; P=0.000), nuclear polymorphism (z=4.22; P=0.000), hyperchromatism (z=3.83; P=0.000) and infiltrations into the connective tissue (z=5.76; P=0.000). The changes unreliable for differentiation are nucleoli (z=1.77; P=0.0763), multinuclear cells (z=0.25; P=0.8041), mitosis (z=1.44; P=0.151), basal membrane lacerations (z=1.07; P=0.2866). The presence of the squamous epithelium in the fibrin and/or granulation tissue involved by granulocytes is a morphological feature of epithelial regeneration. The presence of the squamous epithelium in the cellular connective involved by mononuclears, with prominent nuclear polymorphism, hyperchromatism, monocellular dyskeratosis features the malignant epithelium.Rating:
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R. Ganjanin, I. Klem, Z. Eri, J. Stanic (Sremska Kamenica, Yugoslavia). Bronchial epithelium changes occurring between the 2nd and the 5th post-biopsy day. Eur Respir J 2002; 20: Suppl. 38, 575
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