Source: Annual Congress 2002 - Lung cancer: epidemiology and clinical characteristics
Disease area: Airway diseases

Abstract

Is there a correlation between cytometric sputum abnormality and impairment of lung function? Methods: For the treatment group of heavy smokers in the RIDTELC Lung Study, spirometric results (VC, FVC, FEV1, FEV1%FVC, PEF, MEF50) from 541 male smokers (57.8 ±] 7.1 yrs, 62 ±] 27 pack*yrs cigarette consumption) were correlated with malignancy grade (MG), a measure of DNA distribution of epithelial nuclei, as the outcome of automated sputum cytometry (ASC). Results: 467 smokers with ASC normal sputa and 74 subjects with ASC suspicious sputa had significantly (p < 0.005) decreased lung function when compared to normal predicted values of the European Community, but there was no significant difference between both groups (p>0,05). In addition, no correlation was found between lung function parameters and MG (r< 0.17).

	MG	VC(%pred.)	FVC(%pred.)	FEV1(%red.)	FEV1%VC(%pred)	PEF (% pred.)	MEF50 (%pred.)
ASC normal	0.071±] 0.016	89.3±] 12.9	92.4 ±] 15.1	89.2 ±] 19.6	95.5 ±] 13.7	89.0 ±] 23.4	65.6 ±] 31.6
ASC suspicious	0.138 ±]0.041	90.1 ±] 13.9	90.9 ±] 15.9	87.1 ±] 20.9	95.1 ±] 15.2	86.4 ±] 20.1	60.3 ±] 29.5

Conclusion: In RIDTELC Lung Study participants, interim static and dynamic lung volumes were almost 10% lower than predicted, while mid- and late expiratory flows were reduced to nearly 60%. Thus far we could observe no correlation between reduced lung volumes and airflow limitation and malignancy grade in ASC.

Rating:

Share or cite this content

Citations should be made in the following way:
W. Marek, B. Meiler, M. Abdul-Wahed, Z. Atay, K. H. Jöckel, J. A. Nakhosteen (Bochum, Hannover, Essen, Germany). Interim baseline lung function and cytometry of induced sputum in the treatment group from RIDTLEC lung study. Eur Respir J 2002; 20: Suppl. 38, 574

Member's Comments

No comment yet.

Related content which might interest you: The assessment of immune cells profile in blood and induced sputum in patients with COPD developing lung cancer Source: Eur Respir J 2006; 28: Suppl. 50, 674s Year: 2006 Can semi-automated image cytometry on induced sputum become a screening tool for lung cancer?: Evaluation of quantitative semi-automated sputum cytometry on radon- and uranium-exposed workers Source: Eur Respir J 2001; 18: 942-950 Year: 2001 Flow cytometry vs. immunohistochemistry in determining CD4+/CD8+ cell ratio in BAL fluid from patients with interstitial lung diseases Source: Annual Congress 2010 - Usefulness of bronchoalveolar lavage in diffuse parenchymal lung disease Year: 2010 T cell analyses in blood, BAL and induced sputum from lung transplant recipients Source: Annual Congress 2010 - Pre-operative evaluation and post-operative problems after lung transplantation Year: 2010 Expression of apoptotic markers in lung tissue of COPD patients: preliminary results Source: Eur Respir J 2006; 28: Suppl. 50, 748s Year: 2006 Usefulness of a panel of sputum markers in the evaluation of lung inflammation and functional impairment in symptomatic smokers and COPD patients Source: Annual Congress 2011 - Treatment strategies, systemic manifestations and biomarkers in airway diseases Year: 2011 Blood levels of TNF-α, IFN-γ, IL-10, TGF-β1 and lung functional parameters in patients with advanced and earlier lung sarcoidosis Source: Eur Respir J 2006; 28: Suppl. 50, 676s Year: 2006 Differences in the pattern of FEV1 and VC change after lung resection between lung cancer patients with limited and normal lung function Source: Eur Respir J 2006; 28: Suppl. 50, 278s Year: 2006 Lung function testing for the preoperative evaluation of patients with lung cancer Source: Annual Congress 2003 - Lung function testing for preoperative evaluation in lung cancer patients Year: 2003 Perforin expression in lung tissue of COPD patients: preliminary results Source: Eur Respir J 2007; 30: Suppl. 51, 138s Year: 2007 p16(ink4) expression and spirometry tests have similar survival outcomes values in non-small-cell lung cancer patients Source: International Congress 2015 – Lung cancer: prognostic factors and features of oncogene-driven tumours Year: 2015 Comparison of induced and spontaneous sputum in the diagnosis of lung cancer Source: Eur Respir J 2001; 18: Suppl. 33, 64s Year: 2001 Lung function, clinical status and serum/sputum IL-10 levels in CF patients Source: Eur Respir J 2006; 28: Suppl. 50, 484s Year: 2006 The trend of pulmonary function tests over time in COPD patients with different levels of blood eosinophils Source: International Congress 2016 – Biomarkers and phenotypes of COPD Year: 2016 Expression of MAGE in the induced sputum of lung cancer patients Source: Eur Respir J 2002; 20: Suppl. 38, 595s Year: 2002 Paradoxically normal lung volume assessed by CXR and total lung capacity in patients with diffuse pulmondary fibrosis and additional emphysema Source: Eur Respir J 2006; 28: Suppl. 50, 98s Year: 2006 Effect of low dose pirfenidone on survival and lung function decline in patients with idiopathic pulmonary fibrosis (IPF): results from a real life study Source: Virtual Congress 2021 – News in treatment and diagnosis of idiopathic interstitial pneumonia Year: 2021 Estimated postoperative pulmonary function and 6 months recovery for lobectomized lung cancer patients with and without COPD Source: International Congress 2016 – Surgical strategy for complex diseases Year: 2016 A follow-up study with broncho-alveolar lavage (BAL) to assess the importance of airway colonization in lung transplantation (LTx) Source: Eur Respir J 2006; 28: Suppl. 50, 778s Year: 2006 Pre-treatment lung function decline stabilizes up to 3 year after targeted lung denervation in COPD Source: Virtual Congress 2020 – The hot and cold of interventional pulmonology Year: 2020