Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters
Disease area: Sleep and breathing disorders

Abstract

Increased cardiovascular risk in OSAS can be attributed to an independent risk of the illness OSAS itself and to the presence of already existing cardiovascular risk factors. For the first time these risk factors were investigated in the Netherlands. This retrospective observational study included all newly referred OSAS patients in 2011 to a Dutch teaching hospital (MST) and addressed the presence of already existing cardiovascular risk factors. According to the Framingham model, overall 10-year cardiovascular risk (CVR) was calculated using the variables age, sex, systolic blood pressure (corrected for treatment), smoking, diabetes and cholesterol levels, with a limit of 30%.The overall risk of the OSAS population, for developing a cardiovascular accident in the following 10-year period was 16.5%. This calculated CVR differed between mild (10.9%) and moderate (17.0%) (p<0.001), and between mild and severe (17.8%) OSAS (p<0.001). The use of antihypertensive drugs and anticholesteremic agents increases per OSAS severity (20.9%, 40.9% to 45% and 20.9%, 25.5% to 28% in respectively mild, moderate and severe OSAS).Using the Framingham model, the calculated 10-year risk of general cardiovascular disease, in this population, is elevated up to maximal 17.8% in severe OSAS, and is much less than the previous reported 30% CVR (Kiely JL, Eur Respir J 2000). This could be explained by the differences in population, OSAS severity and risk calculation. Since we used the model for overall CVR, instead of adding the results of 2 models; stroke risk and coronary heart disease risk.In conclusion, overall 10-year cardiovascular risk in a Dutch OSAS population is substantial but lower as reported in earlier studies.

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Citations should be made in the following way:
L. Visscher, M. G. J. Brusse-Keizer, M. M. M. Eijsvogel (Enschede, Netherlands). Obstructive sleep apnoea syndrome and a calculation of cardiovascular risk. Eur Respir J 2014; 44: Suppl. 58, 1752

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