Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters
Disease area: Sleep and breathing disorders

Abstract

Intermittent hypoxia increases purine metabolism and uric acid (UA) production. The Metabolic Syndrome is also associated with hyperuricemia, leading some authors to propose that UA may be used as a marker of increased cardiovascular risk. We analyzed data from 525 patients studied by polysomnography in the Sleep Laboratory of the University Hospital, Palma de Mallorca, Spain to assess: 1) prevalence of hyperuricemia, defined as UA values ³8 mg/dL; 2) the relationships between UA and both OSA severity and metabolic abnormalities. Mean UA in the sample was 6.3±2.6 mg/dL, and UA was increased in 68 patients (prevalence 13%). Compared to patients with normal UA, hyperuricemic patients were older (age±SD 55.3±12.7 vs 50.6±12.7 yr, p=0.005), heavier (BMI 32.9±5.3 vs 30.7±6.3, p=0.007), had more severe OSA (AHI: 56.4±27.0 vs 41.6±27.2, p<0.0001; lowest SaO2: 76-2±10.1 vs 81.4±9.1%, p<0.0001), higher C-reactive protein level (5.2±4.4 vs 3.6±4.8 mg/L, p<0.001), higher creatinine (1.07±0.30 vs 0.93±0.27 mg/dL, p=0.0001), higher insulin resistance (HOMA Index 5.76±3.70 vs 3.52±2.85, p<0.0001) and higher Metabolic Index (3.1±1.0 vs 2.2±1.4, p<0.0001). Weak univariate relationships were found between UA and BMI, AHI, lowest and mean SaO2,creatinine, HOMA ln, and Metabolic Index, explaining each 5 to 9% of UA variability. Stepwise multiple regression identified the following independent correlates of UA (R²=0.23, R=0.48, p<0.0001): gender, creatinine, diuretic treatment, Metabolic Index, and mean SaO2. Results were unchanged after exclusion of 40 diabetic patients. These preliminary data suggest that both intermittent hypoxia and metabolic abnormalities affect UA levels in untreated OSA patients.

Rating:

Share or cite this content

Citations should be made in the following way:
E. Mazzuca, A. M. Marotta, C. I. Gruttad'Auria, A. Castrogiovanni, L. Serafino Agrusa, C. Esquinas, A. Barcelo', F. Barbé, O. Marrone, M. R. Bonsignore (Palermo, Italy; Lleida, Palma de Mallorca, Spain). Prevalence of hyperuricemia in patients with obstructive sleep apnea from the Mallorca cohort. Eur Respir J 2014; 44: Suppl. 58, 1750

Member's Comments

No comment yet.

Related content which might interest you: Prevalence of obstructive sleep apnea syndrome in patients with risk factors for cardiovascular diseases in a large population in Zaragoza (Spain) Source: International Congress 2014 – Sleep disordered breathing 3 Year: 2014 Vasopressin in patients with obstructive sleep apnoea syndrome – An interventional, case-control study Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters Year: 2014 Obstructive sleep apnoea syndrome and a calculation of cardiovascular risk Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters Year: 2014 Gender differences in comorbidity burden in recently diagnosed obstructive sleep apnea patients Source: International Congress 2014 – Sleep disordered breathing 1 Year: 2014 Response to exercise in patients with obstructive sleep apnea Source: International Congress 2014 – Sleep disordered breathing 5 Year: 2014 Acromegaly screening in patients with sleep apnea symptoms Source: International Congress 2014 – Sleep disordered breathing 1 Year: 2014 Prevalence of metabolic syndrome with obstructive sleep apnea in a Korean population Source: Annual Congress 2013 –Sleep disordered breathing in special situations III Year: 2013 Erythrocytosis in patients with obstructive sleep apnea Source: International Congress 2014 – Sleep disordered breathing 1 Year: 2014 Libido disorders in patients with obstructive sleep apnea Source: International Congress 2014 – Sleep disordered breathing: from children to the elderly Year: 2014 Prevalence of obstructive sleep apnea syndrome and CPAP adherence in the elderly Chinese population Source: International Congress 2015 – Measuring sleep-disordered breathing in children and adults I: questionnaires, epidemiology and sleep studies Year: 2015 Prevalence of positional obstructive sleep apnea in a Dutch sleep center population Source: International Congress 2016 – Comorbid sleep apnoea in specific clinical entities and differential diagnosis of sleep disorders Year: 2016 A novel postal-based approach to diagnosing obstructive sleep apnoea in a high risk population Source: International Congress 2014 – Sleep disordered breathing 1 Year: 2014 Effects of age on severity of disease in an obstructive sleep apnea population Source: Annual Congress 2013 –Sleep disordered breathing in special situations II Year: 2013 Familial aggregation of obstructive sleep apnoea in children without tonsillar hypertrophy Source: International Congress 2014 – Three ages of man: OSA in children, adults and the elderly Year: 2014 Predictors of nocturnal hypertension in obstructive sleep apnea patients with metabolic syndrome Source: Annual Congress 2013 –A metabolic medley: sleep disordered breathing Year: 2013 Evaluation of lipid profile in patients with obstructive sleep apnea syndrome Source: International Congress 2015 – To treat or not to treat? Sleep-disordered breathing II Year: 2015 Nocturia is an independent predictive factor of prevalent hypertension in obstructive sleep apnea patients Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters Year: 2014 Obstructive sleep apnoea and hypothyroidism Source: International Congress 2015 – Measuring sleep-disordered breathing in children and adults II: questionnaires, epidemiology and sleep studies Year: 2015 Obstructive sleep apnea in elderly patients: Neuroimage and cognitive function before and after treatment Source: International Congress 2014 – Three ages of man: OSA in children, adults and the elderly Year: 2014 Prevalence of high risk population for obstructive sleep apnea using STOP-BANG questionnaire in a large urban population Source: International Congress 2014 – Sleep disordered breathing 2 Year: 2014