Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters
Disease area: Sleep and breathing disorders

Abstract

Background: Obstructive sleep apnoea (OSA) is known as an independent risk factor associated with cardiovascular disease. Resistant hypertension is prevalent amongst OSA sufferers and this increases the risk of adverse cardiovascular events.Aims: We studied a group of patients who had undergone Maxillomandibular advancement (MMA) surgery for their OSA assessing what benefit, if any, would be observed with regard to blood pressure control.Methods: A retrospective study was performed on consecutive patients with OSA who had MMA between 2002 and 2012. All patients had failed first line CPAP. Pertinent data were retrieved from medical records; focusing upon blood pressure and mean arterial pressure (MAP). Pre-operative results were compared with those observed 6 months following surgery.Results: 51 patients underwent surgery for their OSA. Blood pressure data were available in 45 cases. There was a significant fall in mean systolic blood pressure at 6 months post-surgery (131 +/- 12 compared with 127 +/- 12 mmHg, p<0.001). Additionally, we observed a notable reduction in MAP following surgery (96.6 +/- 10 compared with 93.1 +/- 8 mmHg, p= 0.06). Ten patients in our sample had established hypertension. This sub-group demonstrated a greater fall in the post-operative systolic and diastolic blood pressures and MAP values ( -6mmHg, -10mmHg and -9mmHg, respectively).Conclusions: Our analysis showed a statistically significant fall in blood pressure in patients who had undergone MMA for their OSA. This is likely to be clinically beneficial to these patients given the significant cardiovascular morbidity that is associated with untreated OSA.

Rating:

Share or cite this content

Citations should be made in the following way:
S. Islam, C. Taylor, I. Ormiston (Leicester, Wiltshire, United Kingdom). Beneficial cardiovascular risk factor modification observed in patients with obstructive sleep apnoea following maxillomandibular advancement surgery. Eur Respir J 2014; 44: Suppl. 58, 1748

Member's Comments

No comment yet.

Related content which might interest you: The efficacy of oral appliance in patients with severe obstructive sleep apnea Source: International Congress 2014 – Sleep disordered breathing 2 Year: 2014 Obstructive sleep apnoea and post-operative complications Source: International Congress 2015 – To treat or not to treat, and how? Sleep-disordered breathing I Year: 2015 Obstructive sleep apnoea syndrome and a calculation of cardiovascular risk Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters Year: 2014 Monoblock appliance in children with obstructive sleep apnea is an effective treatment modality Source: International Congress 2014 – Sleep disordered breathing 5 Year: 2014 Effect of obstructive sleep apnea in severity and short-term prognosis of acute coronary syndrome Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters Year: 2014 Role oft sleep position training in the treatment of the positional obstructive sleep apnoe sydrome Source: International Congress 2014 – Sleep disordered breathing 3 Year: 2014 Response to exercise in patients with obstructive sleep apnea Source: International Congress 2014 – Sleep disordered breathing 5 Year: 2014 A novel postal-based approach to diagnosing obstructive sleep apnoea in a high risk population Source: International Congress 2014 – Sleep disordered breathing 1 Year: 2014 Surgery for obstructive sleep apnea: Sleep endoscopy determinants of outcome Source: Annual Congress 2012 - Physiology, obesity and the downstream effects of OSA Year: 2012 Vasopressin in patients with obstructive sleep apnoea syndrome – An interventional, case-control study Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters Year: 2014 Gender differences in comorbidity burden in recently diagnosed obstructive sleep apnea patients Source: International Congress 2014 – Sleep disordered breathing 1 Year: 2014 Prevalence of hyperuricemia in patients with obstructive sleep apnea from the Mallorca cohort Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters Year: 2014 Genetic determinants of cardiovascular disease in patients with obstructive sleep apnea (OSA) Source: International Congress 2015 – Ring of fire: inflammation and metabolism in sleep-disordered breathing Year: 2015 Relationship between hepcidin levels and periodic limb movements in sleep in patients with obstructive sleep apnea syndrome Source: International Congress 2014 – Sleep disordered breathing 1 Year: 2014 Are there any gender differences in presenting symptoms and outcomes in people treated for obstructive sleep apnoea syndrome? Source: International Congress 2014 – Sleep disordered breathing 5 Year: 2014 Nocturia is an independent predictive factor of prevalent hypertension in obstructive sleep apnea patients Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters Year: 2014 Effects of age on severity of disease in an obstructive sleep apnea population Source: Annual Congress 2013 –Sleep disordered breathing in special situations II Year: 2013 Cognitive function was improved after continuous positive airway pressure treatment in obstructive sleep apnea syndrome Source: International Congress 2016 – Technical aspects, compliance, and adherence to positive airway pressure in sleep apnoea Year: 2016 Complications of bariatric surgery in morbid obesity in patients with obstructive sleep apnea syndrome Source: International Congress 2016 – Non-CPAP in obstructive and central sleep apnoea and obesity hypoventilation syndrome Year: 2016 Obstructive sleep apnea in elderly patients: Neuroimage and cognitive function before and after treatment Source: International Congress 2014 – Three ages of man: OSA in children, adults and the elderly Year: 2014