Source: International Congress 2014 – The story continues: impact of OSA on cardiometabolic parameters
Disease area: Sleep and breathing disorders

Abstract

Objectives: Microalbuminuria is an important risk factor for cardiovascular diseases. Microalbuminuria may be seen due to intermittent hypoxemia in patients with obstructive sleep apnea syndrome (OSAS). In this study, we investigated prevalence and relationship of microalbuminuria with clinical and physiological parameters in patients with OSASMethod: Seventy seven patients with OSAS and twenty-one nonapneic snoring subjects upon polysomnography were included in this study. The urinary albumin creatinin ratio (UACR) was calculated according to previously described formula. The severity index of chronic diseases was evaluated by using The Modified Cumulative Illness Rating Scale (MCIRS). Subjective sleepiness was assessed using the epword sleepiness scale (ESS).Results: BMI, MCIRS, UACR, ESS were higher in patients with OSAS than nonapneic snoring subjects. In linear regression model, there was a negative relationship between UARC and minimal O2 and there was a significantly positive relationship between UARC and desaturation index.

Table 1: The Predictors of Urinary albumin creatinin ratio

	UACR	UACR		UACR	UACR
	B values	p values		B values	p values
Age	-0.008	0.9	Age	0.03	0.7
Sex	0.07	0.4	Sex	0.08	0.4
BMI	0.10	0.3	BMI	0.11	0.2
MCIRS	0.06	0.5	MCIRS	0.08	0.4
Minimal O2	-0.27	0.01	DI	0.23	0.03

Conclusion:Microalbuminuria may be seen in patients with OSAS, depending on the severity of disease and hypoxemia. Microalbuminuria in patients with COPD should be examined in regular periods for risk of cardiovascular morbidity or mortality.
Statistical significance p<0.05, UACR: Urinary albumin creatinin ratio, BMI: Body Mass Index MCIRS: The modified cumulative illness rating scale, DI: Desaturation index

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Citations should be made in the following way:
E. Bulcun, A. Ekici, M. Ekici, D. Cimen, U. Kisa (Kirikkale, Turkey). Microalbuminuria in obstrucive sleep apnea syndrome. Eur Respir J 2014; 44: Suppl. 58, 1746

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