Immunohistochemistry versus DNA testing for detection of EGFR mutations and ALK rearrangements in lung adenocarcinoma patients

M. Skronski, R. Langfort, D. Giedronowicz, P. Jagus, A. Szpechcinski, J. Chorostowska-Wynimko (Warsaw, Poland)

Source: International Congress 2014 – Basic and translational research in lung cancer and non-neoplastic pulmonary diseases
Session: Basic and translational research in lung cancer and non-neoplastic pulmonary diseases
Session type: Thematic Poster Session
Number: 816
Disease area: Thoracic oncology

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Skronski, R. Langfort, D. Giedronowicz, P. Jagus, A. Szpechcinski, J. Chorostowska-Wynimko (Warsaw, Poland). Immunohistochemistry versus DNA testing for detection of EGFR mutations and ALK rearrangements in lung adenocarcinoma patients. Eur Respir J 2014; 44: Suppl. 58, 816

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Allele-specific real-time PCR detection of EGFR exon 19 and 21 mutations in various clinical non-small cell lung cancer specimens
Source: International Congress 2014 – Basic and translational research in lung cancer and non-neoplastic pulmonary diseases
Year: 2014

Lung adenocarcinoma with concomitant EGFR mutation and ALK rearrangement: Analysis of two cases and literature review
Source: International Congress 2016 – Basic science and case reports in lung cancer
Year: 2016


Comprehensive analysis of the PTEN domains on TGFbeta-induced aberrant cell motility in lung alveolar/epithelial cells by using PTEN constructs with deletion mutants
Source: International Congress 2014 – Molecular pathogenesis of pulmonary inflammatory diseases (COPD, asthma and ILD)
Year: 2014

RT-PCR and IHC as the alternative methods for detection of ALK aberrations in NSCLC samples - The feasibility study
Source: International Congress 2015 – Promising novel findings in translational pulmonary research
Year: 2015

The phenotypes and serum levels of alpha-1 antitrypsin in lung cancer patients – Preliminary results
Source: International Congress 2014 – Basic and translational research in lung cancer and non-neoplastic pulmonary diseases
Year: 2014

Optimization of cfDNA routine use for NSCLC genomic alteration analysis
Source: International Congress 2016 – How the understanding og molecular and genomic crosstalk is helping to diagnose lung disease
Year: 2016


The methylation profiling of multiple tumor suppressor genes in plasma cell-free DNA from patients with NSCLC versus non-malignant tumors - pilot study
Source: International Congress 2014 – Basic and translational research in lung cancer and non-neoplastic pulmonary diseases
Year: 2014

High-throughput detection of alternative splicing in patients with non-small cell lung cancer treated by bevacizumab/erlotinib
Source: International Congress 2014 – Novel approaches in transcriptomics and epigenomics in inflammatory lung diseases and lung cancer
Year: 2014


Methylation associated pathway activity deregulation in lung adenocarcinoma
Source: International Congress 2014 – Novel approaches in transcriptomics and epigenomics in inflammatory lung diseases and lung cancer
Year: 2014



Defining lineage relationships of multiple lung tumors through shared large genomic rearrangements
Source: Annual Congress 2013 –New strategies in epigenomic research to study lung diseases (DNA rearrangements, RNA, methylation, proteosome)
Year: 2013

Comparative analysis of lung cancer driver mutations from FFPE samples and liquid biopsies by IonTorrent next generation sequencing
Source: International Congress 2016 – Prognostic variables in lung cancer II
Year: 2016


Validation of PNA-LNA PCR clamp assay for detection of EGFR exon 19 and 21 mutations in various types of clinical non-small cell lung cancer specimens
Source: Annual Congress 2013 –Translational research to bridge the need within clinical decision making
Year: 2013

Gene polymorphisms of p53 at codon 72 and MDM2 SNP309 are associated with lung cancer risk and emphysematous changes in smokers
Source: International Congress 2014 – Basic and translational research in lung cancer and non-neoplastic pulmonary diseases
Year: 2014

A detailed immunohistochemical analysis of PI3K/AKT/MTOR pathway in lung cancer: Correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features
Source: Annual Congress 2013 –Prognostic factors and subtyping of lung cancer
Year: 2013

Tumor-associated stromal gene expression signatures predict therapeutic response to erlotinib/bevacizumab in non-small cell lung cancer (NSCLC)
Source: International Congress 2014 – Basic and translational research in lung cancer and non-neoplastic pulmonary diseases
Year: 2014

Surface vs. intracellular CTLA-4 expression in lung cancer
Source: International Congress 2014 – Basic and translational research in lung cancer and non-neoplastic pulmonary diseases
Year: 2014


Prevalence of molecular changes in resected pulmonary adenocarcinomas
Source: International Congress 2016 – Prognostic variables in lung cancer I
Year: 2016


Circulating biomarkers and tumour molecular profiling in patients with non-small cell lung cancer
Source: International Congress 2015 – Biomarkers, immunology and molecular pathology of lung cancer
Year: 2015

Surface expression of CTLA-4 on CD4/CD25high cells in lung cancer
Source: International Congress 2014 – Basic and translational research in lung cancer and non-neoplastic pulmonary diseases
Year: 2014


Telomere-associated gene network in lung adenocarcinoma
Source: International Congress 2015 – Respiratory translational research: novel mechanisms, diagnostic markers and Space Odyssey
Year: 2015