A functional polymorphism in XRCC1 gene is associated with lung cancer risk in a Korean population S. S. Yoo, C. Jin, K. J. Choi, S. Y. Lee, Y. D. Lee, S. Y. Lee, J. Lee, S. I. Cha, C. H. Kim, J. Y. Park (Daegu, Republic Of Korea)
Source: International Congress 2014 – Pathology and prognostic factors of thoracic tumours
Session: Pathology and prognostic factors of thoracic tumours Session type: Poster DiscussionNumber: 514
Disease area: Thoracic oncologyAbstract Defects on DNA repair system are associated with carcinogenesis. It has been reported that a number of XRCC1 polymorphisms are related with lung cancer risk. We investigated the relationship between 5 potentially functional polymorphisms and lung cancer risk in a Korean population. In total, 610 lung cancer patients and 610 healthy controls were enrolled in this case-control study. Among 5 polymorphisms, the rs25489G>A was significantly associated with lung cancer risk (codominant model, odds ratio = 0.65, 95 % confidence interval = 0.49-0.87, P value = 0.003). When stratified according to smoking status, age, gender and tumor histology, the rs25489G>A was associated with lung cancer risk in never smoker, young age, female and adenocarcinoma (P value = 0.004, 0.003. 0.001 and < 0.001, respectively). These findings suggest that the rs25489 of XRCC1 may contribute to genetic susceptibility to lung cancer.Rating:
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S. S. Yoo, C. Jin, K. J. Choi, S. Y. Lee, Y. D. Lee, S. Y. Lee, J. Lee, S. I. Cha, C. H. Kim, J. Y. Park (Daegu, Republic Of Korea). A functional polymorphism in XRCC1 gene is associated with lung cancer risk in a Korean population. Eur Respir J 2014; 44: Suppl. 58, 514
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