Source: International Congress 2014 – Pathology and prognostic factors of thoracic tumours
Disease area: Thoracic oncology

Abstract

Studies suggest that continued smoking after a diagnosis of Lung Cancer (LC) independently worsens quality of life, and shortens life expectancy, but these were retrospective and smoking was not validated biochemically^1,2. We wanted to see if current smoking status independently affects prognosis in newly diagnosed LC.We report early findings from 406 patients with newly diagnosed LC who were followed for at least 6 months. Smoking status was verified by exhaled carbon monoxide (eCO) on every clinical visit.Smoking status was entered alongside performance status and T&M stage as into a multiple regression model with days survived since diagnosis as the dependent variable.73.6% of those who were smoking at the time of diagnosis were alive at 6 months, compared to 81.3% of ex- or never smokers (X²(1, N = 370) = 2.95, p =.57).

Table to show the results of the stepwise multiple linear regression

	Adjusted R2	R2 Change	d.f.	Sig. Value
T Staging	0.040	0.040	1	0.043
T & M Staging	0.089	0.009	2	0.021
T,M staging and Smoking status	0.098	0.019	3	0.014
T,M staging and WHO performance status & Smoking status	0.117	0.019	4	0.011

51% of patients who smoked experienced treatment complications compared to only 41% of patients who did not smoke, (p=.143).Smoking status appears an independent predictor of survival in NSCLC, alongside traditional factors. Quitting smoking could improve mortality. More recruits and data collection regarding histology, treatments and outcomes is ongoing but these results suggest smoking cessation treatments should be offered within LC MDTs and at all follow-up appointments.1. British Medical Journal; BMJ 2010:340:b5569.2. Chest. 2004; 126: 1733-41.

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Citations should be made in the following way:
R. Roberts, K. Lewis (Llanelli, Swansea, United Kingdom). Does smoking status at time of diagnosis of lung cancer independently predict survival at 6 months?. Eur Respir J 2014; 44: Suppl. 58, 504

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