Source: Annual Congress 2002 - Asthma - Therapy and management -3
Disease area: Airway diseases

Abstract

Inhaled corticosteroids are most effective anti-asthma drugs currently available so are now recommended as first-line therapy in asthmatic patients. However, inhaled corticosteroids may have local side-effects due to the deposition of inhaled corticosteroid in the oropharynx. The most common problem is hoarseness and weakness of the voice (dysphonia) which is due to laryngeal deposition. It may occur in up to 40 % of patients and may be a problem particularly in patients who need to use their voices during their work (teacher, singer, etc). We present the findings in 20 patients (47.90±]15.15 years-old and inhaled corticosteroid medication 9.53±]6.70 years) complaining of dysphonia who underwent videostrobolaryngoscopy (VSL). A number of abnormalities were identified. Maximum phonation time was found to be 10.90±]3.08 seconds and that was lower than expected in 19 of 20 patients. Glottic gap was found in 30 % of the patients and that may be due to inefficiency of the subglottic pressure. However, our findings did not confirm the widely suggested views that steroid dysphonia is due primarily to a fungal infection or a steroid-induced adductor myasthenia of the larynx. A larger-scale prospective study is indicated.

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M. Polatli, K. K. Metin, M. Yildiz, M. Cam, G. Erpek, O. Cildag (Aydin, Turkey). Evaluation of dysphonia in asthmatic patients by videostrobolaryngoscopy. Eur Respir J 2002; 20: Suppl. 38, 452

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