Source: Annual Congress 2002 - Asthma - Therapy and management -3
Disease area: Airway diseases

Abstract

Aim: To evaluate the effect of inclusion of antioxidant and trace element complex in basic therapy in patients with asthma. Material: 38 patients (17 males and 11 females, mean age 42,4±]2,3 years) with asthma with prevalence of atopic component, moderate severe, in a phase unstable remission. 12 patients (group 1) received only basis therapy (inhalatory β2-agonists and corticosteroids). 26 patients (group 2) received in addition complex of oral antioxidants (vit. E,C,A, Se, Zn, Q-10, β-carotin) during one month. Methods: spirometry, bodypletysmography, diffusion capacity for CO (single breath and steady state), ([dsquote]MasterLab[dsquote], E. Jaeger, Germany) and blood gases ("AVL", Austria); antioxidant and oxidative damage parameters in peripheral blood: conjugate diene (CD), malonedialdehyde (MDA) in eritrocytes and plasma.
Results: After one month of treatment in group 1 dynamics of all functional and biochemical parameters was absent or was positive, but non-significant. In group 2 we observed positive significant changes of the majority of lung function parameters: decrease of airflow limitation and RV (ΔFEV1=+0,35±]0,11 l, p<0,001; ΔPEF=0,62±]0,30 l/s; ΔMMEF25-75=+0,41±]0,16 l/s, p<0,02; ΔRex=-0,15±]0,06 kPa/l/s, p<0,02; ΔRV= -0,33±]0,15l l, p<0,03); increased of VCin (+0,18±]0,08 l, p<0,05) and DLCOss (+9,75±]5,1 % Pred.). Among of biochemical tests significantly improved CD (-0,47±]0,12 mkmol/l, p<0,05).
Conclusion: The improvement of quality of life in patients with asthma from inclusion in basic therapy the antioxidants results in reduction or liquidation of oxidative body-stress, that is confirmed by the functional and laboratory tests.

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N. T. Panina, N. G. Yakovleva, T. V. Kotenko, L. N. Danilov (St-Petersburg, Russia). Role of antioxidant and trace element complex in outpatient care of bronchial asthma. Eur Respir J 2002; 20: Suppl. 38, 440

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