Source: Annual Congress 2002 - Asthma - Therapy and management -3
Disease area: Airway diseases

Abstract

Our purpose was to study the bronchodilating effects of formoterol (Foradil, Aerolizer - FA) and compare it to fenoterol HFA (Berotec N - FN) during acute asthma exacerbation (AAE).
71 asthmatic patients (33 male, 38 female, average age 42,2 years) were randomized into parallel-group, single-dose, pilot trial. Measurements of FEV₁ in 1,3,5,7,10,15,20 minutes after inhalation of FA 12μg (n=18) and 24μg (n=16), and FN 100μg (n=18) and 200μg (n=20)were performed.
We revealed the onset of action of both FA and FN in 1 minute after inhalation. Effects of FA were stronger in first 5 minutes in comparison with FN. FEV₁ in 3 minutes was 11.07 per-cent and 12.94 per-cent for FA (12μg and 24μg) versus 7.18 per-cent and 8.32 per-cent for FN (100μg and 200μg). A response time (increasing FEV₁ on 12 per-cent from baseline) was 3.7 min. and 2.9 min. for FA (12μg and 24μg), whereas 4.8 min. and 5.4 min for FN (100μg and 200μg).
Conclusions:
1. The onset of actions of FA and FN are the same in AAE
2. The degree of the bronchodilating effect of FA is higher than effect of FN within first 5 minutes.
3. Formoterol (Aerolizer) can be successfully used for curing of acute asthma exacerbations.

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Citations should be made in the following way:
I. A. Stitsenko (St-Petersburg, Russia). Formoterol (aerolizer) in acute asthma exacerbation. Eur Respir J 2002; 20: Suppl. 38, 438

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