Source: Annual Congress 2002 - Asthma: Inflammation, hyperreactivity, treatment side effects
Disease area: Airway diseases

Abstract

The aim of this study was to investigate the influence of inhaled corticosteroids (ICS) on intraocular pressure (IOP) in asthmatics with primary open angle glaucoma with and without family history of glaucoma. Three hundred and five glaucomatous patients with visual field defects, optic disc changes and elevated IOP and 145 control subjects participated in the study. Twenty asthmatics treated with ICS were found to form three groups: I group - 4 asthmatics with glaucoma that have family history of glaucoma, II group - 9 asthmatics with glaucoma without family history of glaucoma and III group - 7 asthmatics without glaucoma. The asthmatic patients with glaucoma and family history have higher IOP than those with glaucoma without family history - IOP mmHg = 26.6±]2.7 vs. 23.2±]3.6 (p<0.05) and showed more severe visual field defects - Mean Deviation 7.6±]4.1 vs 2.7±]2.8 (p<0.05). IOP was normal (16.0±]3.1 mm Hg) in all asthmatics without glaucoma except one subject who showed an ocular hypertensive response to ICS. The results support the hypothesis that the patients with family glaucoma inherit not only glaucoma disease but also increased susceptibility to corticosteroids. In conclusion, glaucomatous asthmatics on ICS, exspecially those with family history of glaucoma, need special care and follow-up by ophthalmologist.

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Citations should be made in the following way:
M. Konareva-Kostianeva, S. Kostianev, P. Strumeliev (Plovdiv, Bulgaria). Influence of inhaled corticosteroids on intraocular pressure in patients with asthma and glaucoma. Eur Respir J 2002; 20: Suppl. 38, 433

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