Source: Annual Congress 2002 - Asthma: Inflammation, hyperreactivity, treatment side effects
Disease area: Airway diseases

Abstract

Glucocorticoids are widely used for patients with bronchial asthma (BA). They are effective antiinflammatory, immune correcting and antiallergic agents. However, long-term steroid therapy can result in the development of osteoporosis. A parallel group study of the relationship between steroid therapy and reduction in the osseous tissue mineral density (OTMD) was performed. Group I comprised 40 males with BA aged 55±]7 years who received 15 mg prednisolone daily for four years; group II, 50 BA patients aged 46±]8 years who received 500-1000 mg flunisolide daily for four years; a control group, 60 patients with chronic obstructive bronchitis taking no glucocorticoids. Double X-ray absorptiometry was used for diagnosing OTMD. Blood levels of calcium, phosphor, alkaline phosphatase, cortisol and testosterone were determined.
Osteoporosis with predominant spongy bone tissue involvement was found in 46% patients taking prednisolone vs. 5% patients taking flunisolide. Osteopenia was detected in 42 and 34% patients receiving prednisolone and flunisolide, respectively. 80% patients in the control group had normal OTMD value. Osteopenia revealed in 20% controls was probably age-related or caused by smoking, theophylline administration, etc.
In conclusion, inhalation vs. oral corticosteroids have significantly lower rates of side effects as regards OTMD.

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Citations should be made in the following way:
A. S. Dubrovsky, E. P. Haritonova, I. M. Lapteva (Minsk, Belarus). Effect of oral and inhalation corticosteroids on osseous tissue condition for patients with bronchial asthma. Eur Respir J 2002; 20: Suppl. 38, 432

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