Source: Annual Congress 2002 - Asthma: Inflammation, hyperreactivity, treatment side effects
Disease area: Airway diseases

Abstract

Cough variant asthma (CVA) and atopic cough (AC) are different clinical manifestations of eosinophilic airway inflammation presenting with isolated chronic non-productive cough. Longitudinal change of pulmonary function in CVA and AC is unknown. Thus, we examined the longitudinal change of FEV1 in patients with CVA and AC.
Twenty patients with CVA, 14 patients with AC and 271 asymptomatic healthy subjects were prospectively examined. Thirteen patients with CVA were taking long-term inhaled corticosteroid therapy (ICS) (beclomethasone dipropionate 615 ±] 58 μg/day) and other 7 patients were not. Spirometry was taken at first visit, after cough was almost completely relieved on therapy and at least once every year for 5 or more years afterwards.
Slope of longitudinal change in FEV1 was -0.029 ±] 0.007, –0.021 ±] 0.022 and -0.028 ±] 0.002 l/year in CVA patients, AC patients and asymptomatic subjects, respectively, and these values were not significantly different. In patients with CVA, the slope in patients without ICS was –0.032 ±] 0.007 l/year, which was not different from that in patients with ICS (-0.027 ±] 0.010 l/year).
The pulmonary function decline is not greater in CVA than AC and normal population, and long-term ICS has no benefit for the decline in CVA.

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Citations should be made in the following way:
M. Fujimura, M. Nishitsuji, Y. Nishizawa, T. Kita (Ishikawa, Kanazawa, Japan). Longitudinal decline of pulmonary function in cough variant asthma and atopic cough. Eur Respir J 2002; 20: Suppl. 38, 429

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