Source: Annual Congress 2002 - Asthma: Inflammation, hyperreactivity, treatment side effects
Disease area: Airway diseases

Abstract

Aim of the study was to investigate the effect of GER on airway responsiveness (AR) to methacholine, physical exercise and on cough reflex, in bronchial asthma. Twenty nine asthmatic patients underwent 24 hours pH monitoring, airway challenges with methacholine, physical exercise and capsaicin. The results were expressed as PD20 methacholine, PD5 capsaicin (dose causing five coughs) and DFEV1 (maximal percent decrease of FEV1 after seven min exercise). AR was measured again after 12 days treatment with omeprazole (40 mg daily). Comparison of asthmatics with and without GER, showed no significant difference in basal FEV1, PD20, PD5 and DFEV1. There was no correlation between the results of airway challenges and GER parameters. FEV1, PD20 and DFEV1 did not change after omeprazole, but treatment significantly decreased sensitivity to capsaicin, tough only in patients with GER (PD5 basal 0.15, range 0.07-0.61 nM; after treatment 2.46, range 0.07-9.84 nM; p<0.01). There was no relationship between PD5 variation induced by treatment (difference between PD5 values after treatment and under basal conditions) and GER in the distal oesophagus. On the contrary, in GER positive patients, we found a significant positive relationship between PD5 variation on one hand, the number of refluxes (r= 0.67, p<0.01) and acid exposure time (r= 0.76, p<0.001) in the proximal oesophagus on the other. In conclusion, AR to methacholine and exercise seems not to be related with GER, and is not influenced by gastric acid secretion inhibition. On the contrary, acid suppression does reduce cough sensitivity to capsaicin, which seems to be related to the presence of reflux in proximal rather than in distal oesophagus.

Rating:

Share or cite this content

Citations should be made in the following way:
M. Ferrarri, E. Brotto, L. Benini, C. Segattini, R. Zanon, M. Bertaiola (Verona, Italy). Gastro-oesophageal reflux (GER) and airway responsiveness to methacholine, physical exercise and capsaicin in bronchial asthma: effect of gastric acid secretion inhibition. Eur Respir J 2002; 20: Suppl. 38, 426

Member's Comments

No comment yet.

Related content which might interest you: Laryngeal vs bronchial hyperresponsiveness Source: Annual Congress 2005 - PG8 - Vocal cord dysfunction Year: 2005 Tiotropium reduction of lung inflammation in a model of chronic gastro-oesophageal reflux Source: Eur Respir J 2010; 35: 1370-1376 Year: 2010 High IL-8 levels correlating with a neutrophilic airway inflammation in children with respiratory symptoms and gastroesophageal reflux (GER) Source: Eur Respir J 2002; 20: Suppl. 38, 379s Year: 2002 Levels of exhaled nitric oxide (e-NO) are related to acid-induced hyper-responsiveness to MCh in non-atopic patients with gastro-esophageal reflux (GER) and persistent cough Source: Eur Respir J 2003; 22: Suppl. 45, 413s Year: 2003 The role of airway neurogenic inflammation in gastro-esophageal reflux induced cough Source: Eur Respir J 2005; 26: Suppl. 49, 302s Year: 2005 Bronchial hyperresponsiveness study in patients with gastroesophageal reflux Source: Eur Respir J 2004; 24: Suppl. 48, 586s Year: 2004 Airway inflammation in severe asthmatics with gastro-oesophageal reflux Source: International Congress 2017 – Diagnostic tools and comorbidities in paediatric asthma Year: 2017 Cough response to inhaled capsaicin in children with suspect and confirmed gastroesophageal reflux disease Source: Annual Congress 2007 - Current issues in airway physiology, pharmacology and monitoring Year: 2007 Gastroesophageal reflux and hyperreactivity of bronchial tree in children with CF Source: Eur Respir J 2003; 22: Suppl. 45, 230s Year: 2003 Bronchial asthma and gastro-oesophageal reflux Source: ISSN=1025-448x, ISBN=1-904097-26-x, page=260 Year: 2003 Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation Source: Eur Respir J 2002; 20: 268-273 Year: 2002 The evaluation of bronchial hyperreactivity in gastroesophageal reflux disease and the outcome of antiinflamatory therapy Source: Eur Respir J 2004; 24: Suppl. 48, 133s Year: 2004 Role of oesophageal acidification in gastroesophageal reflux (GOR) related cough Source: Eur Respir J 2002; 20: Suppl. 38, 450s Year: 2002 Airway inflammation in patients with chronic cough caused by gastroesophageal reflux Source: International Congress 2017 – Best clinical practice for the management of chronic lung diseases Year: 2017 Gastro-oesophageal reflux disease and bronchial asthma Source: Eur Respir J 2002; 20: Suppl. 38, 50s Year: 2002 Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux Source: Eur Respir J, 54 (4) 1901805; 10.1183/13993003.01805-2019 Year: 2019 Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux Source: Eur Respir J, 54 (4) 1901376; 10.1183/13993003.01376-2019 Year: 2019 The presence of acid in oesophagus does not influence exercise-induced airway narrowing Source: Eur Respir J 2006; 28: Suppl. 50, 222s Year: 2006 Role of tissue kallikrein 1 in late phase bronchoconstriction and airway hyperresponsiveness Source: Annual Congress 2006 - Basic mechanisms of allergic airways inflammation Year: 2006 Cough during airway challenges: associations with bronchoconstriction and asthma Source: Annual Congress 2005 - Experimental approaches to the study of chronic cough and cigarette smoking Year: 2005