Source: Annual Congress 2002 - Asthma: Inflammation, hyperreactivity, treatment side effects
Disease area: Airway diseases

Abstract

Among adult women, chronic cough (CC) is a common concern wich can be due to various diseases. Cough may often be the sole clinical presentation of asthma and in such patients, the finding of bronchial hyperresponsiveness (BHR)may confirm the diagnosis.
Thus, we studied bronchial responsiveness in 85 women (mean age 49 yrs +/- 9) with CC compared to 21 women (mean age 45 +/- 8 yrs) with asthma-likesymptoms. BHR was assessed by a carbachol challenge to determine the PD20 necessary to decrease basal FEV1 by 20%. Before the challenge, all the patients had normal ventilatory parameters and no differences were observed between the 2 groups (CC : FEV1 2530 +/- 58 mL, FEV1/FVC : 80 +/-1% ; asthma-like symptoms : FEV1 : 2462 +/- 175 mL, FEV1/FVC : 79 +/- 2%). In women with CC, BHR was less frequent than in women with asthma-like symptoms (PD20 : CC 722+/-80 vs 395 +/-94 micrograms for asthma-like symptoms, p = 0.02 t Student).Among asthma-like women, no differences were observed between responders and non responders regarding basal respiratory parameters. CC women with positive challenge exhibited lower FEF25-75 than non responder CC patients (81+/-4 vs 91+/-3% of predicted value, respectively). However, FEF25-75 values were into normal bounds.
In conclusion, no respiratory parameter may predicted bronchial hyperresponsiveness. Therefore, the diagnosis of asthma in women with CC and normal basal pulmonary function tests still requires bronchial challenge by carbachol or metacholine.

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Citations should be made in the following way:
G. Kouevidgin, S. Pontier, D. Riviere, C. Hermant, R. Escamilla (Toulouse, France). Bronchial responsiveness in 85 adult women with chronic cough. Eur Respir J 2002; 20: Suppl. 38, 425

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