Source: Annual Congress 2002 - Asthma: Inflammation, hyperreactivity, treatment side effects
Disease area: Airway diseases

Abstract

Quality of Life (QoL) measurements are more responsive to clinically significant changes. The aim of this study was to examine the relationship between bronchial hyperresponsiveness (BHR), age, sex, smoking and QoL in asthmatic patients.
277 asthmatics subjects underwent clinical visit, prick test, pulmonary function and MCHt (methacholine challenge test) and completed the Asthma Questionnaire Life Quality (AQLQ).
Of 140 subjects with positive MCHt 121 were positive to prick test while 19 were negative. Of 137 subjects with negative MCHt 98 were positive to prick test while 39 were negative. Subjects with positive MCHt have lower values of QoL than subjects with negative MCHt. For all 32 items asthmatic subjects have median values of 4.8 (4.2-4.9) compared to 5.7 (4.7-6.3) of patients with negative MCHt. For physical activities subjects with positive MCHt showed median values of 5.1 (4.5-6.0) compared to 5.8 (4.8-6.3) of subjects with negative MCHt (p<0.05). Median scores of 12 items of symptoms and 5 items of emotions in subjects with positive MCHt were 4.5 (3.7-5.8) and 5.1 (4.2-6.1) significantly lower (p<0.01) than 5.4 (4.4-6.1) and 6.3 (5.2-6.9) respectively, of subjects with negative MCHt. For items of environmental stimuli the median score was 4.7 (3.7-5.9) in subjects with positive MCHt, significantly lower than 5.4 (4.2-6.4) in subjects with negative MCHt (p<0.05). Among several classes of age only 21-29 years have a worsening of QoL compared to other classes in the symptoms domain. The QoL of our subjects not results significantly limited by sex and smoking.
The presence of BHR may identify a set of patients who may benefit from man adeguate pharmacological treatment resulting an improvement of parameters measuring QoL.

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Citations should be made in the following way:
G. Riccioni, E. Ballone, F. Di Giulio, M. T. Guagnano, S. Sensi, R. Della Vecchia (Chieti, Italy). Bronchial hyperresponsiveness, age, sex, cigarette smoke and quality of life in asthmatic subjects. Eur Respir J 2002; 20: Suppl. 38, 423

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