Source: Annual Congress 2002 - Asthma: Inflammation, hyperreactivity, treatment side effects
Disease area: Airway diseases

Abstract

BACKGROUND:
Current treatment guidelines define inhaled corticosteroids as the cornerstone of antiinflammatory therapy for asthma.
AIM:
Our objective was to assess the correlation between bronchoconstrictor and bronchodilator responsiveness and bronchial inflammation in asthma.
MATERIALS AND METHODS:
54 asthmatic patients (aged 18 to 38) with no history of corticosteroid treatment, neither inhaled nor systemic, were recruited into this study. Antiinflammatory treatment for our patients consisted in inhaled corticosteroids, in doses corresponding to each own respective severity stage, according to GHINA criteria. Mitigation of bronchial inflammation was certified subjectively through a symptoms-questionary revealing significant clinical improvement, and objectively through normalization of basal ventilatory volumes and flow parameters, as well as that of blood and BAL fluid eosinophils count. At the same time we observed that bronchoconstrictor and bronchodilator tests became negative.
CONCLUSION:
A significant decrease in the bronchomotor responsiveness in successfully treated asthmatic patients might prove to be a good predictor of diminishing airway inflammation.

Rating:

Share or cite this content

Citations should be made in the following way:
A. I. Rascu, E. Naghi, L. Bucur, A. Serbescu (Bucharest, Romania). Correlation between bronchial hyperresponsiveness and bronchial inflammation in asthmatic patients. Eur Respir J 2002; 20: Suppl. 38, 420

Member's Comments

No comment yet.

Related content which might interest you: Relationship between bronchial hyperresponsiveness and response to β2-agonists in steroid-naïve patients with mild asthma Source: Eur Respir J 2002; 20: Suppl. 38, 503s Year: 2002 Allergen-induced nonspecific bronchial hyperresponsiveness in patients with intermittent asthma Source: Annual Congress 2009 - Airway hyperresponsiveness: mechanism and assessment Year: 2009 Bronchial hyperreactivity and airway inflammatory markers in nonasthmatic rhinitis Source: Eur Respir J 2003; 22: Suppl. 45, 476s Year: 2003 Bronchial reversibility and airway inflammation in patients with COPD Source: Eur Respir J 2003; 22: Suppl. 45, 436s Year: 2003 Mechanisms of bronchial hyperresponsiveness in asthma Source: Annual Congress 2009 - PG13 Asthma: pathology and treatment Year: 2009 Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD Source: Eur Respir J 2012; 40: 1098-1105 Year: 2012 Galectn-3 : marker of airway inflammation in bronchial asthma Source: International Congress 2018 – Studying novel biomarkers in asthma and COPD Year: 2018 Upper and lower airway inflammation and bronchial hyperresponsiveness in allergic rhinitis children with or without asthma Source: Annual Congress 2011 - Biological correlates and comorbidities of childhood asthma/allergy Year: 2011 Small airways involvement is associated with bronchial hyperresponsiveness in asthma Source: Annual Congress 2012 - Different ways to phenotype asthma Year: 2012 Airway inflammation in symptomatic and asymptomatic subjects with and without airway hyperresponsiveness Source: Eur Respir J 2001; 18: Suppl. 33, 315s Year: 2001 Analysis of airway inflammation in allergic subjects with asymptomatic increased airway response to methacholine Source: Eur Respir J 2006; 28: Suppl. 50, 678s Year: 2006 Monitoring asthma in children: lung function, bronchial hyperresponsiveness and inflammation Source: International Congress 2014 – Monitoring asthma in children: results of the ERS Task Force Year: 2014 Sputum eosinophilia, airway hyperresponsiveness and airway narrowing in young adults with former asthma Source: Eur Respir J 2005; 26: Suppl. 49, 733s Year: 2005 IPL576,092 reduces allergen-induced late asthmatic responses, sputum eosinophilia and airway hyperresponsiveness in mild asthma Source: Eur Respir J 2003; 22: Suppl. 45, 104s Year: 2003 Evaluation of bronchial hyperreactivity and hypersensitivity in asthmatics and bronchitis patients Source: Eur Respir J 2004; 24: Suppl. 48, 587s Year: 2004 Association of inflammation and bronchial hyperresponsiveness Source: Annual Congress 2011 - COPD mechanisms Year: 2011 Influence of endogenous corticosteroids on bronchial protective properties of β2-agonist in patients with bronchial asthma with cold bronchial hyperresponsiveness Source: Annual Congress 2010 - Regulation of airway hyperresponsiveness and bronchodilators Year: 2010 Bronchial hyperreactivity in children with cough variant of bronchial asthma Source: Eur Respir J 2002; 20: Suppl. 38, 473s Year: 2002 Relationship of atopy, asthma severity and bronchial hyperresponsiveness Source: Eur Respir J 2001; 18: Suppl. 33, 429s Year: 2001