Source: Annual Congress 2002 - Asthma: Inflammation, hyperreactivity, treatment side effects
Disease area: Airway diseases

Abstract

Airway inflammation can be demonstrated in mild asthmatic patients who are not treated with inhaled steroids. The measurement of exhaled nitric oxide (NO) is recognized as a marker of airway inflammation. The aim of this study was to evaluate the changes in NO and bronchial hyperresponsiveness (BHR) following treatment with budesonide.
Exhaled NO, spirometry and BHR were measured in 8 steroid-naive mild asthmatics (FEV1 >80%pred) at recruitment, during 12 weeks of inhaled budesonide (400 mcg daily by Turbohaler). A group of 8 normal subjects was also evaluated for baseline comparison. Baseline exhaled NO was significantly increased in asthma compared with control (18.7 vs. 5.1 ppb, p<0.05). After treatment with budesonide, there was a in 3,4-fold decrease (p=0.024) of exhaled NO level. There was an improvement in lung function (FEV1 by 18.8% (p=0.013)), and 4,3-fold (p=0.023) increase of PC20 to histamine. At baseline, significant correlation were observed between FEV1 and PC20 histamine (r=0.58; p=0.048). Exhaled NO did not correlate with PC20 or FEV1.
It is likely that exhaled NO and PC20 may be an index of airway inflammation and therapeutic response in mild asthma, and represent different aspects of the inflammatory process, which are all inhibited by inhaled budesonide.

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E. K. Anaev, A. V. Cherniak, N. A. Voznesensky, A. G. Chuchalin (Moscow, Russia). Exhaled nitric oxide and bronchial hyperresponsiveness in steroid-naive patients with asthma. Eur Respir J 2002; 20: Suppl. 38, 418

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