Source: Annual Congress 2002 - Asthma: Inflammation, hyperreactivity, treatment side effects
Disease area: Airway diseases

Abstract

The aim of the study was to investigate the relationship between reactive oxygen species (ROS) generation in peripheral blood and exhaled nitric oxide (ENO) in patients with atopic mild bronchial asthma in exacerbation.
Materials and methods. All patients (n=21) were non- or ex-smokers, steroid-naive. Control group was consisted of 12 healthy volunteers. ENO was measured by the chemiluminescence analyzer (Logan Research-2149). ROS generation was evaluated by luminol- and lucigenin-depended spontaneous (SCL) and latex-activated chemiluminescence (ACL). The intensive of chemiluminescence (ICL) was calculated for each patients (ICL = ACL/SCL).
Results. ENO levels in patients were significantly increased compared to controls (23,5±]10,4 vs 5,12±]2,56). In patients lucigenin-depended ICL was 21,2±]3,2 and luminol-depended ICL was 7,2±]2,0. In controls lucigenin-depended ICL was 4,1±]0,7 and luminol-depended ICL was 3,7±]1,0. We found the correlation between superoxide generation and ENO in patients (r = 0,78). Also we found indirect correlation between ROS generation and ENO in patients (r= -0,72). We conclude that changes in ROS generation were related to reaction between NO and superoxide, that might be a significant feature in asthma exacerbation.

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S. K. Soodaeva, K. S. Dulin, N. A. Voznesensky, A. G. Chuchalin (Moscow, Russia). Reactive oxygen species generation and exhaled nitric oxide in atopic mild bronchial asthma in exacerbation. Eur Respir J 2002; 20: Suppl. 38, 417

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