Source: Annual Congress 2002 - Asthma - Therapy and management -2
Disease area: Airway diseases

Abstract

Introduction: It is suggested that LAB/IS combination inhalers may improve compliance with asthma therapy, as only one inhaler is used for both regular therapies, and rapid clinical improvement (from the Β2 agonist component) provides a feedback system. Method: Dinlink GP prescribing data was analysed as a surrogate marker for compliance. Patient numbers and mean (standard deviation [SD]) prescriptions/year (P) for 100 practices were analysed for SFC, fluticasone propionate (FP), salmeterol (S) and beclometasone disk inhaler (BDH) (for beclometasone only BDH was evaluated, as equivalent metered dose inhalers contain >one month's medication at recommended doses). Good compliance was evaluated as collection of >=80% prescriptions/year (Price D, Thorax 1995).
Results:

	SFC	FP	S	BDH
No. patients	720	3073	366	2829
Mean (SD)	10.0 (5.3)	8.9 (6.5)	9.4 (5.5)	8.2 (6.1)
Compliance (%)	83	74	78	68
Treatment difference (vs SFC)		1.1	0.6	1.8
95% confidence interval		0.6,1.6	0.2,1.0	1.1,2.5
p value (SFC vs comparators)		<0.0001	<0.0001	=0.008

Discussion: Prescribing data are only a surrogate for compliance as patients may not use all prescriptions written for them. However, the differences between SFC and the other regular therapies prescribed were highly significant, and only SFC achieved the >=80% standard for good compliance. This study shows SFC to be associated with good patient compliance, with mean prescriptions approaching the ideal of 1/month more closely than other regular asthma medications.

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Citations should be made in the following way:
T. P. McCarthy, M. S. Russell, L. Rice, S. Patel (Uxbridge, United Kingdom). Improved patient compliance with salmeterol/fluticasone propionate combination (SFC) compared with regular long-acting β2 agonist (LAB) and inhaled steroid (IS) therapy. Eur Respir J 2002; 20: Suppl. 38, 409

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