Source: Annual Congress 2002 - Asthma - Therapy and management -2
Disease area: Airway diseases

Abstract

Introduction Administration of antihistamines in addition to topical corticosteroids is not uncommon in everyday practice for patients with severe symptoms of allergic rhinitis although there is a lack of enough data on the efficacy of such a combination therapy. The aim of this study was to investigate the efficacy of budesonide alone or in combination with cetirizine on symptoms of allergic rhinitis in patients with severe seasonal allergic rhinitis and astma.
Material and Methods This randomised, placebo controlled, double-blind prospective clinical trial was performed on 214 patients with severe seasonal allergic rhinitis and asthma. Seventy-three patients received only budesonide aqueous nasal spray (400μg/day) and placebo tablets whereas 70 patients received budesonide aqueous nasal spray (400μg/day) in combination to cetirizine tablets (10 mg/day) for 3 weeks. Seventy-one patients received placebo spray and tablets for the same period. Reduction of nasal and ophthalmic symptom scores were compared between groups.
Results Both treatment regimens were found to be effective for reducing nasal and ophthalmic symptom scores compared to the placebo. The combination regimen was not more effective than budesonide alone for controlling any parameter studied.
Conclusion Budesonide nasal spray can be used alone for sufficient nasal and ocular symptom control with low incidence of side effects for patients with severe symptoms of allergic rhinitis. In case of insufficient symptom control, combination of an agent other than cetirizine may be considered.

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Citations should be made in the following way:
M. Ozcan, K. M. Ozcan, I. Olcay (Ankara, Turkey). Budesonide nasal spray alone or in combination with cetirizine in patients with severe seasonal allergic rhinitis and asthma. Eur Respir J 2002; 20: Suppl. 38, 399

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