Source: Annual Congress 2002 - Asthma - Therapy and management -1
Disease area: Airway diseases

Abstract

Aim: To evaluate the cost-effectiveness of reliever therapy with formoterol 4.5 μg Turbuhaler® (Oxis®) and salbutamol 200 μg via a pMDI or dry powder inhaler (DPI). 18,124 patients, aged 4–91 years, with different severities of asthma and receiving a variety of maintenance medications, entered this randomised, 6-month, open, parallel-group trial. Cost of study drug, direct and indirect costs of exacerbations and health care resource use due to asthma were collected using year 2000 prices in Sweden and Spain. Results: Exacerbations and healthcare resource use were considerably lower on formoterol compared with salbutamol: hospitalised days –27%, emergency treatments –20%, health-care contacts –8%, days with inability to conduct normal activities –10%; and the number of symptom free days was higher (+3%). Formoterol versus salbutamol by pMDI (generic or cheapest) resulted in no significant increase in total cost in Sweden (+7%) and a modest increase in Spain (+15%; significant). Conclusion: In Sweden, formoterol reliever therapy resulted in similar total daily cost compared with the most common salbutamol DPI. Reliever therapy with Oxis® improved asthma control with no increase or a modest increase in total daily costs compared with the most commonly used and cheapest alternatives in Sweden and Spain.

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Cost-effectiveness of formoterol turbuhaler versus salbutamol as reliever therapy in asthma: results from the RELIEF worldwide randomised effectiveness study. Eur Respir J 2002; 20: Suppl. 38, 389

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