Source: Annual Congress 2002 - Airway obstruction measurement (FOT - NEP) sleep and lung sound analysis
Disease area: Sleep and breathing disorders

Abstract

Apnoeic events are often accompanied by heart rate shifts (HRS) and a rise in blood pressure, resulting in a decrease in the pulse transit time (PTT). This may result in an arousal, as observed on standard electroencephalography (EEG). To understand the relationships between arousals from standard polysomnography and data from PTT recordings, we have carried out a preliminary comparison study.
Methods: 17 patients had simultaneous sleep study recordings using the SleepLab 1000e (Jaeger) and the RM60 (DeVilbiss), which records PTT. All recordings were manually analysed by one scorer, with arousals scored according to ASDA criteria. Data are given as mean ±] SEM.
Results: The hours of recording from each system was identical (5.6 ±] 0.5 hr) and pre-study Epworth score 13.7 ±] 1.5. From polysomnography, the arousals/hour (AI) was 15.3 ±] 2.6 and apnoea-hypopnoea index (AHI) was 10.8 ±] 1.9. From the RM60, the PTT/hr was 33.6 ±] 4.0 and the HRS/hour was 49.4 ±] 6.1. There were no significant individual correlations between PTT, AI or AHI. However, when combined, multiple regression analysis produced: PTT/hr = 8.11 - 0.064 AI + 0.409 HRS/hr + 0.582 AHI, r² = 0.61, p = 0.005.
Conclusion: This preliminary study suggests that Pulse Transit Time provides a simple surrogate marker of the combined effects of apnoeas, hypopnoeas and arousals obtained from full polysomnography. Further work is required to fully evaluate this technique and compare it to full polysomnography, as well as determining the effects of using PTT to predict response to nasal continuous positive airway pressure (nCPAP).

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Citations should be made in the following way:
F. Buchanan, N. Wiltshire, J. R. Catterall, A. H. Kendrick (Bristol, United Kingdom). Pulse transit time: comparison to polysomnographic studies. Eur Respir J 2002; 20: Suppl. 38, 321

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