Source: Annual Congress 2002 - Airway obstruction measurement (FOT - NEP) sleep and lung sound analysis
Disease area: Airway diseases, Interstitial lung diseases

Abstract

Idiopathic pulmonary fibrosis (IPF) is characterized by an increased lung elastic recoil (CR). We evaluated whether the impulsed oscillometry system (IOS) reflects the changes of elastic properties in patients with IPF. We observed 25 patients (48 ±]3 yrs) with total lung capacity (TLC) less 80 % predicted values (% pred). Vital capacity (VC), TLC, forced expiratory volume in one second (FEV₁), plethysmographic airway resistance (Raw), elastic pressure at 100 % TLC (Pel100%), dynamic lung compliance (CLdyn), static lung compliance (CLst) and CR were measured. Using IOS, the respiratory impedance (Z), its real (R) and virtual (X) parts at 5 and 20 Hz and resonance frequency (RF) were determined. We used the predicted values of Vogel and Smidt for IOS parameters. Results: TLC = 58,6±]2,7 % pred, FEV₁/VC = 106,0±]2,2 % pred, Raw = 0,37±]0,03 kPa/l/s, Pel100% = 214,6±]16,3 % pred, CLdyn = 26,6±]2,5 % pred, CLst = 21,1±]3,7 % pred, CR = 1,77±]0,14 kPa/l, Z = 143,8 ±]7,0 % pred, R5 = 124,8±]5,2 % pred, R20 = 103,0±]3,5 % pred, X5 = -0,25±]0,02 kPa/l/s, RF = 18,6±]0,8 Hz. Z and R5 were moderately correlated with CR and Pel100% but not with CLdyn and CLst. X5 was moderately correlated with CR, CLdyn, CLst but not with Pel100%. RF was strongly correlated with CR and moderately correlated with Pel100%, CLdyn and CLst.
Conclusion: The changes of IOS parameters were not specific in patients with IPF but they may reflect the changes of elastic properties in such patients.

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Citations should be made in the following way:
L. D. Kiryukhina, L. N. Novikova, M. Y. Kameneva, E. S. Aganezova (St-Petersburg, Russia). Respiratory impedance in patients with idiopathic pulmonary fibrosis. Eur Respir J 2002; 20: Suppl. 38, 316

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