Source: Annual Congress 2002 - Airway obstruction measurement (FOT - NEP) sleep and lung sound analysis
Disease area: Interstitial lung diseases

Abstract

The forced oscillation techique (FOT) is a non invasive method to measure mechanical impedance of respiratory system. Aim of our study was to evaluate resistance (R5-R20) and reactance (X5-X20) in patients with scleroderma, idiopathic pulmonary fibrosis (IPF) and connective tissue diseases.
We studied 8 patients with connective tissue diseases: systemic lupus erythematosus (SLE) and Rheumatiod arthritis, group A ( mean age 59±]14 yr; 1 male), 16 patients with diagnosis of scleroderma, group B (mean age 57±]11yr; 1 male) and 10 patients with IPF, group C (mean age 62±]11yr; 7 males). Total resipiratory resistance and reactance at 5 Hz and 20 Hz (frequency of impulse generated by the oscillator) were performed by means of the FOT. We measured FVC, FEV1, R5, R20, X5 and X20. We observed in group C a statistical decrease of R5, R20, X20 and a statistical increase in X5 compared to group A; a statistical decrease in R20, X20 and increase in X5 compared to group B. However no significant differences were found between group A and B (table). We conclude that FOT tecnique, as the spirometric test, is a sensitive method to follow up severe interstitial lung disesase.

Groups	FVC%	FEV1%	R5%	R20%	X5%	X20%
C	56±]12	61±]13	91±]20	71±]19	882±]699	29±]88
B	85±]10	86±]21	110±]34	101±]29	341±]256	324±]240
p	<0.02	<0.02	ns	<0.02	<0.05	<0.05

Groups	FVC%	FEV1%	R5%	R20%	X5%	X20%
C	56±]12	61±]13	91±]20	71±]19	882±]699	29±]88
A	92±]11	80±]8	132±]33	114±]22	218±]421	129±]87
p	<0.02	<0.02	<0.02	<0.01	<0.05	<0.05

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Citations should be made in the following way:
E. Bucchioni, V. Fasano, M. Mastrangelo, R. Bossi, L. Allegra (Milan, Italy). Forced oscillation technique in patient with scleroderma, idiopathic pulmonary fibrosis (IPF) and connective tissue diseases. Eur Respir J 2002; 20: Suppl. 38, 313

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