Source: Annual Congress 2002 - Cellular reactions in allergy in humans and animals
Disease area: Airway diseases

Abstract

Specific immunotherapy have been previously demonstrated to be an effective treatment for the cause of allergic asthma. However, its mechanisms has not been fully elucidated. Our objectives were to explore the effects of high concentration antigen on induction of T cells anergy and its mechanisms.
In the study, the T cells from ovalbumin-sensitized Balb/c mice were treated with different concentration of ovalbumin and monocytes as antigen-presenting cells(APCs) in vitro , then the production of IL-5 and the expression of CD28 on T cells and CD86 on monocytes were determined.
Low concentrations ovalbumin stimulated antigen-specific T cells to produce markedly higher levels of IL-5 than the controls (P<0.001). However, the production of IL-5 by T cells treated with high-concentration (10mg/ml) antigen decreased significantly to the level of the controls. Similarly, the increase of CD86 expression on APCs treated by low concentrations antigen was observed. But high concentration antigen induced the decrease of CD86 expression. This results suggested that high concentration allergen could induce T cell from allergic mice anergy. The mechanisms related to depression of costimulatory signal CD86 expression on the APCs.

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Citations should be made in the following way:
C. Z. Wang, K. Sun (Chongqing, China). High concentration of antigen induces allergic mice T cells anergy with depressing CD86 expression on antigen-presenting cells. Eur Respir J 2002; 20: Suppl. 38, 298

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